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Sirtinol

SIGMA/S7942 - ≥95% (HPLC)

Synonym: 2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

CAS Number: 410536-97-9
Empirical Formula (Hill Notation): C26H22N2O2
Molecular Weight: 394.47
MDL Number: MFCD00810186
Linear Formula: C26H22N2O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S7942-1MG 1 mg
 $109.00
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45-S7942-5MG 5 mg
 $389.00
1/EA		 Add To Favorites

 

assay ≥95% (HPLC)
form solid
InChI 1S/C26H22N2O2/c1-18(19-9-3-2-4-10-19)28-26(30)22-13-7-8-14-24(22)27-17-23-21-12-6-5-11-20(21)15-16-25(23)29/h2-18,29H,1H3,(H,28,30)/b27-17+
InChI key UXJFDYIHRJGPFS-WPWMEQJKSA-N
Quality Level 200 
SMILES string CC(NC(=O)c1ccccc1N=Cc2c(O)ccc3ccccc23)c4ccccc4
solubility DMSO: soluble
storage temp. −20°C
Application: HUVEC were treated with sirtinol to study the effect on induction of transcription factor Krüppel-like factor 2.4 Sirtinol was used to treat human embryonic kidney cells to study the effect on the expression on Werner syndrome protein.5
Biochem/physiol Actions: Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p and human SIRT2 deacetylase activity in vitro. It inhibits the physiological regulators of platelet aggregation such as thrombin and collagen, attenuates intracellular Ca2+ release and formation thromboxane B2. It may increase levels of cAMP by inhibition of cAMP phosphodiesterase and inhibit the aggregation of platelets.2 Sirtinol reduces inflammatory responses of human dermal microvascular endothelial cells to TNF-α and IL-1β.3
Biochem/physiol Actions: Sirtinol inhibits yeast Sir2p transcriptional silencing activity in vivo, yeast Sir2p, and human SIRT2 deacetylase activity in vitro.
Features and Benefits: This compound is a featured product for Gene Regulation research. Click here  to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95% (HPLC)
Storage Temp. −20°C
UNSPSC 12352203

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