Synonym: (+)-(4S)-6-Fluorospiro[chroman-4,4′-imidazolidine]-2′,5′-dione; (4S)-6-Fluoro-2,3-dihydro-spiro[4H-1-benzopyran-4,4′-imidazolidine]-2′,5′-dione; CP 45634
CAS Number: 68367-52-2
Empirical Formula (Hill Notation): C11H9FN2O3
Molecular Weight: 236.20
MDL Number: MFCD00867380
Linear Formula: C11H9FN2O3
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white to off-white |
| form |
powder |
| InChI |
1S/C11H9FN2O3/c12-6-1-2-8-7(5-6)11(3-4-17-8)9(15)13-10(16)14-11/h1-2,5H,3-4H2,(H2,13,14,15,16)/t11-/m0/s1 |
| InChI key |
LXANPKRCLVQAOG-NSHDSACASA-N |
| optical activity |
[α]/D +50 to +60°, c = 1 in methanol |
| Quality Level |
100  |
| SMILES string |
Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 |
| solubility |
DMSO: ≥20 mg/mL |
| storage temp. |
2-8°C |
| Application: |
Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group. |
| Application: |
Sorbinil may be used in cell signaling and neuroscience studies. |
| Biochem/physiol Actions: |
Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy. |
| Biochem/physiol Actions: |
Sorbinil is an inhibitor of Aldose Reductase (AR). AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer. |
| Biochem/physiol Actions: |
Sorbinil is an inhibitor of Aldose Reductase. |
| Disclaimer: |
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| Features and Benefits: |
This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| Hazard Codes |
Xn |
| Risk Statements |
22 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| Storage Temp. |
2-8°C |
| UNSPSC |
12352200 |
