Sorbinil
SIGMA/S7701 - ≥98% (HPLC)
Synonym: (+)
CAS Number: 68367-52-2
Empirical Formula (Hill Notation): C11H9FN2O3
Molecular Weight: 236.20
MDL Number: MFCD00867380
Linear Formula: C11H9FN2O3
Product Type: Chemical
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This image depicts S7701-5MG.
This image depicts S7701-5MG.
| assay | ≥98% (HPLC) |
| color | white to off-white |
| form | powder |
| InChI | 1S/C11H9FN2O3/c12-6-1-2-8 |
| InChI key | LXANPKRCLVQAOG-NSHDSACASA |
| optical activity | [α]/D +50 to +60°, c = 1 in methanol |
| Quality Level | 100  |
| SMILES string | Fc1ccc2OCC[C@]3(NC(=O)NC3 |
| solubility | DMSO: ≥20 mg/mL |
| storage temp. | 2-8°C |
| Application: | Sorbinil has been used as an aldose reductase inhibitor in diabetic rats as a positive control group. |
| Application: | Sorbinil may be used in cell signaling and neuroscience studies. |
| Biochem/physiol Actions: | Sorbinil decreases the level of sorbitol in red blood cells and increases the velocity of nerve conduction. It maintains the myo-inositol content in the nerve and prevents the reduction of sodium-potassium ATPase activity. This action is beneficial in providing symptomatic relief in patients with diabetic neuropathy. |
| Biochem/physiol Actions: | Sorbinil is an inhibitor of Aldose Reductase (AR). AR family members AKR1B1 and AKR1B10 have additionally been shown to play roles in inflammation and cancer. |
| Biochem/physiol Actions: | Sorbinil is an inhibitor of Aldose Reductase. |
| Disclaimer: | RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization. |
| Features and Benefits: | This compound is featured on the Dopamine and Norepinephrine Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302 |
| Hazard Codes | Xn |
| Risk Statements | 22 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352200 |