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Spiperone

SIGMA/S7395 - solid

Synonym: 8-[3-(p-Fluorobenzoyl)propyl]-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one; R 5147; Spiroperidol

CAS Number: 749-02-0
Empirical Formula (Hill Notation): C23H26FN3O2
Molecular Weight: 395.47
EC Number: 212-024-0
MDL Number: MFCD00055099
Linear Formula: C23H26FN3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S7395-250MG 250 mg
 $163.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S7395-250MG

 

color light yellow
form solid
InChI 1S/C23H26FN3O2/c24-19-10-8-18(9-11-19)21(28)7-4-14-26-15-12-23(13-16-26)22(29)25-17-27(23)20-5-2-1-3-6-20/h1-3,5-6,8-11H,4,7,12-17H2,(H,25,29)
InChI key DKGZKTPJOSAWFA-UHFFFAOYSA-N
Quality Level 200 
SMILES string Fc1ccc(cc1)C(=O)CCCN2CCC3(CC2)N(CNC3=O)c4ccccc4
solubility 0.1 M HCl: slightly soluble 0.3 mg/mL
  45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 2 mg/mL
  ethanol: 1.5 mg/mL
  H2O: slightly soluble 0.2 mg/mL
Application: Spiperone has been used to block the actions of 5-hydroxytryptamine (5-HT) receptor. It also has been used to study its anti tumor effects in glioblastoma (GBM) cell lines.
Application: Spiperone was used to study the role of dopamine receptors in facilitating the male sexual behavior in quails.6
Biochem/physiol Actions: Selective D2 dopamine receptor antagonist; α1B-adrenoceptor antagonist; mixed 5-HT2A/5-HT1 serotonin receptor antagonist; antipsychotic.
General description: Spiperone is a butyrophenone antipsychotic agent. It induces calcium-dependent chloride secretion in the airway and functions as a potential therapeutic target for cystic fibrosis.
Packaging: 250 mg in glass bottle
Preparation Note: Solutions may be stored for 1-2 days at 4 °C.
UNSPSC 12352200

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