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SB 202190 monohydrochloride hydrate

SIGMA/S7076 - ≥98% (HPLC)

Synonym: 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole monohydrochloride hydrate; 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride hydrate

CAS Number: 350228-36-3 (anhydrous)
Empirical Formula (Hill Notation): C20H14FN3O · HCl · xH2O
Molecular Weight: 367.80 (anhydrous basis)
MDL Number: MFCD17215958
Linear Formula: C20H14FN3O · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S7076-5MG 5 mg
 $138.00
1/EA		 Add To Favorites
45-S7076-25MG 25 mg
 $560.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color white to beige
form solid
InChI 1S/C20H14FN3O.ClH.H2O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15;;/h1-12,25H,(H,23,24);1H;1H2
InChI key CZZOICWZVYZUNP-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string O.Cl.Oc1ccc(cc1)-c2nc(-c3ccc(F)cc3)c([nH]2)-c4ccncc4
solubility DMSO: ≥12 mg/mL
storage condition desiccated
storage temp. 2-8°C
Application: SB 202190 may be used to inhibit p38-mediated cell signaling.
Application: SB 202190 monohydrochloride hydrate has been used as a component of human prostate culture medium and organoid culture medium It has also been used as p38 mitogen activated protein kinase (MAPK) inhibitor in colon cancer cells.
Biochem/physiol Actions: SB 202190 binds within the ATP pocket of p38 kinase and inhibits the p38α and β isoforms.
Biochem/physiol Actions: SB 202190 is a highly selective, potent, and cell-permeable inhibitor of p38 MAP kinase.
Biochem/physiol Actions: SB 202190 monohydrochloride hydrate mediates the phosphorylation of serine in the mutant p53 protein and modulates cell adhesion and prevents cell proliferation in breast cancer cell lines.
Features and Benefits: This compound is featured on the MAPKs  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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