Synonym: Sertraline HCl; (1S,4S)-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine hydrochloride
CAS Number: 79559-97-0
Empirical Formula (Hill Notation): C17H17NCl2 · HCl
Molecular Weight: 342.69
MDL Number: MFCD00895772
Linear Formula: C17H17NCl2 · HCl
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white |
| form |
powder |
| InChI |
1S/C17H17Cl2N.ClH/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11;/h2-6,8,10,12,17,20H,7,9H2,1H3;1H/t12-,17-;/m0./s1 |
| InChI key |
BLFQGGGGFNSJKA-XHXSRVRCSA-N |
| optical activity |
[α]/D +33 to +43°, c = 2.0 in methanol |
| Quality Level |
100  |
| SMILES string |
ClC1=C(Cl)C=CC([C@H]2C3=C(C=CC=C3)[C@@H](NC)CC2)=C1.[H]Cl |
| solubility |
DMSO: >20 mg/mL |
| storage condition |
desiccated |
| Application: |
The effect of exposure of sertraline hydrochloride was studied in chronically prepared ovine fetus. It was used in glucocorticoid function assay to study the effect of antidepressants on glucocorticoid receptor function in humans. |
| Biochem/physiol Actions: |
Selective serotonin reuptake inhibitor, antidepressant. |
| Biochem/physiol Actions: |
Sertraline suppresses platelet function and exhibits antiplatelet and endothelium protective functions. It relieves depression and improves the quality of life in patients with cardiovascular disorders. It can also be prescribed to treat depression in Parkinson′s disease. |
| Features and Benefits: |
This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm . |
| Features and Benefits: |
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here . |
| Packaging: |
10, 50 mg in glass bottle |
| Purity |
≥98% (HPLC) |
| UNSPSC |
12352200 |