L-Sulforaphane
SIGMA/S6317 - ≥95% (HPLC), oil
Synonym: (R)
CAS Number: 142825-10-3
Empirical Formula (Hill Notation): C6H11NOS2
Molecular Weight: 177.29
MDL Number: MFCD09039283
Linear Formula: C6H11NOS2
Product Type: Chemical
| assay | ≥95% (HPLC) |
| color | light yellow |
| form | oil |
| InChI | 1S/C6H11NOS2/c1-10(8)5-3- |
| InChI key | SUVMJBTUFCVSAD-SNVBAGLBSA |
| optical activity | [α]/D -70 to -90°, c = 1.0 in chloroform-d |
| Quality Level | 100  |
| SMILES string | CS(=O)CCCCN=C=S |
| solubility | DMSO: >5 mg/mL |
| storage temp. | −20°C |
| Application: | L-Sulforaphane was used to study Nrf2-mediated signaling in mouse primary preadipocytes6 and murine macrophage RAW 264.7 cell line.7 |
| Biochem/physiol Actions: | L-Sulforaphane is a potent, selective inducer of phase II detoxification enzymes with anticarcinogenic properties. Organosulfur compound found in cruciferous vegetables, including broccoli. |
| Biochem/physiol Actions: | Sulforaphane is an anti-cancer, anti-microbial and anti-diabetic compound found in cruciferous vegetables.3,4 It induces the production of detoxifying enzymes such as quinone reductase and glutathione S-transferase that cause xenobiotic transformation. Sulforaphane also increases the transcription of tumor suppressor proteins and inhibits histone deacetylases. It modulates inflammatory responses by suppressing the LPS-mediated expression of iNOS, COX-2, IL-1β and TNF-α.3,5 |
| Packaging: | 5 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |