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SB-505124 hydrochloride hydrate

SIGMA/S4696 - ≥98% (HPLC)

Synonym: 2-(5-Benzo[1,3]dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride hydrate

CAS Number: 694433-59-5 (free base)
Empirical Formula (Hill Notation): C20H21N3O2 · xHCl · yH2O
Molecular Weight: 335.40 (anhydrous free base basis)
MDL Number: MFCD11045901
Linear Formula: C20H21N3O2 · xHCl · yH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4696-5MG 5 mg
 $280.00
1/EA		 Add To Favorites
45-S4696-25MG 25 mg
 $980.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color yellow
form powder
InChI 1S/C20H21N3O2.ClH.H2O/c1-12-6-5-7-14(21-12)18-17(22-19(23-18)20(2,3)4)13-8-9-15-16(10-13)25-11-24-15;;/h5-10H,11H2,1-4H3,(H,22,23);1H;1H2
InChI key DIDCCMVWCVRTNB-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string O.Cl.Cc1cccc(n1)-c2[nH]c(nc2-c3ccc4OCOc4c3)C(C)(C)C
solubility DMSO: >10 mg/mL
  H2O: insoluble
storage condition desiccated
storage temp. 2-8°C
Application: SB-505124 hydrochloride hydrate was used to study the role of TGF-β pathway in development and differentiation studies.3,4
Biochem/physiol Actions: SB-505124 is an inhibitor of activin receptor-like kinase (ALK) 5, also known as transforming growth factor-α type I receptor kinase, with an IC50 of 47 ± 5 nM.
Biochem/physiol Actions: SB-505124 selectively inhibits TGF-β type I receptors, activin receptor-like kinases (ALK) 4, 5 and 7. It inhibits ALK4-, 5- and 7-mediated activation of Smad2, Smad3 and MAPK pathway induced by TGF-β.1 SB-505124 inhibits the human fibroblast trans-differentiation induced by the co-culture with Esophageal squamous cell carcinoma.2
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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