Salinomycin

SIGMA/S4526 - from Streptomyces albus, ≥98% (HPLC)

CAS Number: 53003-10-4
Empirical Formula (Hill Notation): C₄₂H₇₀O₁₁
Molecular Weight: 751.00
EC Number: 258-290-1
Linear Formula: C₄₂H₇₀O₁₁
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S4526-5MG	5 mg	$243.00 1/EA	Add To Favorites
45-S4526-25MG	25 mg	$769.00 1/EA	Add To Favorites
45-S4526-50MG	50 mg	$1370.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S4526-25MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	neoplastics
assay	≥98% (HPLC)
biological source	Streptomyces albus
InChI	1S/C42H70O11/c1-11-29(38(46)47)31-15-14-23(4)36(50-31)27(8)34(44)26(7)35(45)30(12-2)37-24(5)22-25(6)41(51-37)19-16-32(43)42(53-41)21-20-39(10,52-42)33-17-18-40(48,13-3)28(9)49-33/h16,19,23-34,36-37,43-44,48H,11-15,17-18,20-22H2,1-10H3,(H,46,47)/t23-,24-,25+,26-,27-,28-,29+,30-,31+,32+,33+,34+,36+,37-,39-,40+,41-,42-/m0/s1
InChI key	KQXDHUJYNAXLNZ-XQSDOZFQSA-N
mode of action	cell membrane \| interferes
mp	112.5-113.5 °C (lit.)
Quality Level	200
SMILES string	CC[C@H]([C@H]1CC[C@H](C)[C@@H](O1)[C@@H](C)[C@H](O)[C@H](C)C(=O)[C@H](CC)[C@H]2O[C@@]3(O[C@@]4(CC[C@](C)(O4)[C@H]5CC[C@](O)(CC)[C@H](C)O5)[C@H](O)C=C3)[C@H](C)C[C@@H]2C)C(O)=O
storage temp.	2-8°C

Application:	Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44⁺CD24^- mesenchymal-like subpopulation within breast carcinomas.
Biochem/physiol Actions:	Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.
General description:	Chemical structure: polyether
Packaging:	5, 25, 50 mg in glass bottle

Symbol	GHS06
Signal word	Danger
Hazard statements	H300
Precautionary statements	P264 - P270 - P301 + P310 - P405 - P501
Hazard Codes	T
Risk Statements	25
Safety Statements	45
RIDADR	UN 3462 6.1 / PGII
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
mp	112.5-113.5 °C (lit.)
Storage Temp.	2-8°C
UNSPSC	12352200

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