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SB-277011-A hydrochloride hydrate

SIGMA/S4326 - ≥98% (HPLC)

CAS Number: 215804-67-4 (anhydrous)
Empirical Formula (Hill Notation): C28H30N4O · HCl · xH2O
Molecular Weight: 475.02 (anhydrous basis)
MDL Number: MFCD16875431
Linear Formula: C28H30N4O · HCl · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4326-5MG 5 mg
 $173.00
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45-S4326-25MG 25 mg
 $475.00
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assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C28H30N4O.ClH.H2O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);1H;1H2/t20-,24-;;
InChI key OOWNBQACGIKNGM-ONAIBGCWSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string O.Cl.O=C(N[C@@H]1CC[C@H](CC1)CCN2CCc3cc(ccc3C2)C#N)c4ccnc5ccccc45
solubility DMSO: 2 mg/mL, clear (warmed)
storage condition protect from light
storage temp. 2-8°C
Application: SB-277011-A hydrochloride hydrate has been used:
• as a dopamine D3 receptor-selective antagonist in rats to test its effect on 4-propyl-9-hydroxynaphthoxazine ([3H]-(+)-PHNO) radiotracer in cerebellum L9/10 and striatum
• as an acetylcholine inhibitor to test its negative allosteric modulation on Ascaris suum nicotinic acetylcholine receptor (Asu-ACR-16) expressed in Xenopus oocytes and its inhibitory effect on locomotion in Caenorhabditis elegans
• to test its effect on alcohol consumption in mice
Application: SB-277011-A hydrochloride hydrate may be used in D3 dopamine receptor-mediated cell signaling studies.
Biochem/physiol Actions: SB-277011-A is a potent, selective brain-penetrant D3 dopamine receptor antagonist; 80-100x selective for D3 over D2; pKi = 7.95 for hD3 receptor.
Biochem/physiol Actions: SB-277011-A is the most selective D3 dopamine receptor antagonist.
Biochem/physiol Actions: The D3 dopamine receptor antagonist, SB-277011-A inhibits the cocaine-seeking behavior and cocaine-enhances brain stimulation reward in in rats. It decreases drug-seeking behavior and may be useful in treatment of cocaine and methamphetamine addiction.
Features and Benefits: This compound is featured on the Dopamine Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

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