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SB 431542 hydrate

SIGMA/S4317 - ≥98% (HPLC), powder

Synonym: 4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate; 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate; 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate

CAS Number: 301836-41-9 (anhydrous)
Empirical Formula (Hill Notation): C22H16N4O3 · xH2O
Molecular Weight: 384.39 (anhydrous basis)
MDL Number: MFCD11045982
Linear Formula: C22H16N4O3 · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-S4317-5MG 5 mg
 $192.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: S4317-5MG

 

assay ≥98% (HPLC)
form powder
InChI 1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
InChI key WQUIJVKNPYBZOF-UHFFFAOYSA-N
originator GlaxoSmithKline
Quality Level 100 
SMILES string O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5
solubility DMSO: soluble 10 mg/mL
  H2O: insoluble
storage temp. −20°C
Application: SB-431542 was used to study the correlation of platelet-derived growth factor receptor B expression and TGF-β pathway activation in colorectal tumor cells. It was used to study the role of TGF-β signaling in modulation of extracellular matrix and myoblast differentiation.
Biochem/physiol Actions: Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.
Biochem/physiol Actions: SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.
Features and Benefits: This compound was developed by GlaxoSmithKline . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Legal Information: Sold for research purposes under agreement from Glaxo­Smith­Kline
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 51111800

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