D-Serine

SIGMA/S4250 - ≥98% (TLC)

Synonym: β-Hydroxyalanine; (R)-2-Amino-3-hydroxypropionic acid; Ser

CAS Number: 312-84-5
Empirical Formula (Hill Notation): C₃H₇NO₃
Molecular Weight: 105.09
EC Number: 206-229-4
MDL Number: MFCD00004269
Linear Formula: C₃H₇NO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S4250-5G	5 g	$52.40 1/EA	Add To Favorites
45-S4250-25G	25 g	$203.00 1/EA	Add To Favorites

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This image depicts SKU: S4250-5G

Properties
Descriptions
Safety Info.
Basic Data

application(s)	cell analysis
assay	≥98% (TLC)
color	white to off-white
form	powder
InChI	1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m1/s1
InChI key	MTCFGRXMJLQNBG-UWTATZPHSA-N
Quality Level	200
SMILES string	N[C@H](CO)C(O)=O
technique(s)	ligand binding assay: suitable

Application:	D-serine has been used as a substrate in D-amino acid oxidase (DAO) activity in human 1321N1 astrocytoma cells. It has also been used in intracerebroventricular administration in rat for the induction of antinociceptive effect.
Application:	D-serine has been used to prevent glycine-dependent desensitization of N-methyl D-aspartate receptor (NMDAR) and to study its effects on NMDARs to correct behavioral abnormalities in rats after partial sciatic nerve ligation (PSNL).
Biochem/physiol Actions:	D-serine is essential for the normal development of dendrites, neuroblast migration and may have therapeutic potential for treating schizophrenia and depression states. The levels of D-serine is elevated in traumatic brain injury (TBI).
Biochem/physiol Actions:	D-serine is an agonist and glycine mimic which is active at the strychnine-insensitive glycine binding site associated with the N-methyl-D-aspartate (NMDA) receptor as well as the inhibitory post-synaptic glycine receptor. Along with glutamate, it has a role in various physiological processes including synaptic plasticity and receptor transmission. Dysregulation of D-serine signaling has been linked with neurodegenerative diseases and disorders.
General description:	D-serine is a dextro amino acid present in neurons, astrocytes, and microglia. It is synthesized from L-serine by the enzyme serine racemase. Racemase also catalyzes the breakdown of D-serine into ammonia and pyruvate. It is oxidized to hydroxypyruvate by D-amino acid oxidase.
General description:	D-serine is an unusual amino acid expressed in the mammalian brain.
Packaging:	5, 25 g in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (TLC)
UNSPSC	12352209

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