SKF-83959 hydrobromide
SIGMA/S2816 - ≥98% (HPLC), solid
Synonym: 6-
CAS Number: 80751-85-5
Empirical Formula (Hill Notation): C18H20NClO2 · HBr
Molecular Weight: 398.72
MDL Number: MFCD03792727
Linear Formula: C18H20NClO2 · HBr
Product Type: Chemical
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts S2816-5MG.
This image depicts S2816-5MG.
| assay | ≥98% (HPLC) |
| color | white |
| form | solid |
| InChI | 1S/C18H20ClNO2.BrH/c1-11- |
| InChI key | FHYWNBUFNGHNCP-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | Br[H].CN1CCc2c(Cl)c(O)c(O |
| solubility | DMSO: >20 mg/mL |
| H2O: insoluble |
| Application: | SKF-83959 was used in dopamine signaling studies on eye blinking in monkeys and on phosphorylation of CaMKIIα in mice. |
| Biochem/physiol Actions: | D1 dopamine receptor agonist. Displays antagonist activity in vitro and agonist activity in vivo. |
| Biochem/physiol Actions: | SKF-83959 is an atypical agonist of D1 dopamine receptor and an allosteric modulator of σ-1 receptor on in brain and liver tissues. It has neuroprotective and anti-parkinsonian effects through selective activation of phosphoinositol-linked D1 receptor and promotes migration of cultures astrocytes by ERK1/2 activation. In in vitro studies SKF-83959 exhibits antagonist activity against dopamine D1 receptors coupled to adenylyl cyclase. |
| Packaging: | 5, 25 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| UNSPSC | 12352200 |