SIS3

SIGMA/S0447 - ≥98% (HPLC), powder

Synonym: (2E)-1-(6,7-Dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-3-(1-methyl-2-phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-propenone hydrochloride

CAS Number: 521984-48-5
Empirical Formula (Hill Notation): C₂₈H₂₇N₃O₃ · HCl
Molecular Weight: 489.99
MDL Number: MFCD09265258
Linear Formula: C₂₈H₂₇N₃O₃ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-S0447-5MG	5 mg	$454.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	yellow
form	powder
InChI	1S/C28H27N3O3.ClH/c1-30-27(19-8-5-4-6-9-19)22(23-10-7-14-29-28(23)30)11-12-26(32)31-15-13-20-16-24(33-2)25(34-3)17-21(20)18-31;/h4-12,14,16-17H,13,15,18H2,1-3H3;1H/b12-11+;
InChI key	CDKIEBFIMCSCBB-CALJPSDSSA-N
Quality Level	100
SMILES string	Cl.COc1cc2CCN(Cc2cc1OC)C(=O)C=Cc3c(-c4ccccc4)n(C)c5ncccc35
solubility	DMSO: >20 mg/mL
	H₂O: <2 mg/mL
storage temp.	2-8°C

Application:	Sugar insensitive 3 (SIS3) has been used as smad3 inhibitor in various cells.
Biochem/physiol Actions:	SIS3 is a novel specific inhibitor of TGF-β1/ALK-5 phosphorylation of Smad3
Biochem/physiol Actions:	Sugar insensitive 3 (SIS3) promotes drug-induced apoptosis and hinders the function of adenosine triphosphate (ATP)-binding cassette (ABC) transporter (ABCB1) and ABCG2. It resensitizes ABCB1 and ABCG2 overexpressed in cancerous cells, which contributes to chemotherapeutics.
Packaging:	5 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352200

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