Rapamycin
SIGMA/R8781 - Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus
Synonym: 23,27-
Empirical Formula (Hill Notation): C51H79NO13
Molecular Weight: 914.17
EC Number: 200-664-3
Linear Formula: C51H79NO13
Product Type: Chemical
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| antibiotic activity spectrum | fungi |
| yeast | |
| assay | ≥95% (HPLC) |
| autoignition temp. | 301 °C |
| biological source | Streptomyces hygroscopicus |
| color | colorless to yellow |
| concentration | 2.5 mg/mL in DMSO (2.74 mM) |
| form | solution |
| mode of action | enzyme | inhibits |
| Quality Level | 300  |
| storage temp. | −20°C |
| vapor pressure | 0.56 hPa ( 20 °C) |
| Application: | Rapamycin has been used: • as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling • to treat the Drosophila S2 cells at 65-70% confluence, • to measure protein synthesis • to stimulate autophagy in ovarian cancer cells |
| General description: | Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1. |
| General description: | Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age. |
| Other Notes: | 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research  |
| Other Notes: | Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic. Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website. |
| Packaging: | 200uL |
| RIDADR | NA 1993 / PGIII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 188.6 °F - closed cup |
| Flash Point(C) | 87 °C - closed cup |
| Purity | ≥95% (HPLC) |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |