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Razoxane

SIGMA/R8657 - >98% (HPLC)

Synonym: (±)-1,2-Bis(3,5-dioxopiperazin-1-yl)propane; (±)-1,2-Bis(3,5-dioxopiperazinyl)propane; 1,2-Bis(3,5-dioxo-1-piperazinyl)propane; 4,4′-Propylenebis(2,6-piperazinedione); ICI 59118; ICRF 159; NSC 129943; Razoxin; Tepirone; Troxozone

CAS Number: 21416-67-1
Empirical Formula (Hill Notation): C11H16N4O4
Molecular Weight: 268.27
EC Number: 244-379-2
MDL Number: MFCD00430424
Linear Formula: C11H16N4O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R8657-5MG 5 mg
 $123.00
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assay >98% (HPLC)
form solid
InChI 1S/C11H16N4O4/c1-7(15-5-10(18)13-11(19)6-15)2-14-3-8(16)12-9(17)4-14/h7H,2-6H2,1H3,(H,12,16,17)(H,13,18,19)
InChI key BMKDZUISNHGIBY-UHFFFAOYSA-N
Quality Level 100 
SMILES string CC(CN1CC(=O)NC(=O)C1)N2CC(=O)NC(=O)C2
solubility DMSO: 40 mg/mL
storage temp. room temp
Biochem/physiol Actions: Razoxane is clinically active against angiogenesis and metastasis. Razoxane specifically inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor). It is an antimitotic agent with immunosuppressive properties. Razoxane inhibits blood-borne and lymphatic metastases in different experimental models. Studies have shown that razoxane inhibits specifically the vasculogenic mimicry of B16F10 melanoma cells.
Biochem/physiol Actions: Razoxane is clinically active against angiogenesis and metastasis; inhibits topoisomerase II without inducing DNA strand breaks (topo II catalytic inhibitor).
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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