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RRD-251 hydrochloride

SIGMA/R7532 - ≥98% (HPLC)

Synonym: (2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride; 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride; Rb/Raf-1 disruptor 251 hydrochloride; S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride

CAS Number: 72214-67-6
Empirical Formula (Hill Notation): C8H8Cl2N2S· HCl
Molecular Weight: 271.59
MDL Number: MFCD00035047
Linear Formula: C8H8Cl2N2S· HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-R7532-5MG 5 mg
 $59.90
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assay ≥98% (HPLC)
color white to off-white
form powder
InChI 1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H
InChI key COMNQRICZGJVLE-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.NC(=N)SCc1ccc(Cl)cc1Cl
solubility DMSO: >10 mg/mL
  H2O: >2 mg/mL
storage condition desiccated
storage temp. room temp
Biochem/physiol Actions: RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction.
Biochem/physiol Actions: RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.
Packaging: 5, 25 mg in glass bottle
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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