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PF-562,271

SIGMA/PZ0387 - ≥98% (HPLC)

Synonym: N-(3-(((2-((2,3-Dihydro-2-oxo-1H-indol-5-yl)amino)-5- (trifluoromethyl)-4-pyrimidinyl)amino)methyl)-2-pyridinyl)-N-methyl-methanesulfonamide benzenesulfonate; PF 562271; PF-00562271; PF-562271

CAS Number: 939791-38-5
Empirical Formula (Hill Notation): C21H20F3N7O3S · C6H6O3S
Molecular Weight: 665.66
MDL Number: MFCD14105612
Linear Formula: C21H20F3N7O3S · C6H6O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0387-5MG 5 mg
 $178.00
1/EA		 Add To Favorites
45-PZ0387-25MG 25 mg
 $467.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts PZ0387-5MG.

 

assay ≥98% (HPLC)
color white to brown
form powder
InChI 1S/C21H20F3N7O3S.C6H6O3S/c1-31(35(2,33)34)19-12(4-3-7-25-19)10-26-18-15(21(22,23)24)11-27-20(30-18)28-14-5-6-16-13(8-14)9-17(32)29-16;7-10(8,9)6-4-2-1-3-5-6/h3-8,11H,9-10H2,1-2H3,(H,29,32)(H2,26,27,28,30);1-5H,(H,7,8,9)
InChI key LKLWTLXTOVZFAE-UHFFFAOYSA-N
SMILES string CN(S(=O)(C)=O)C1=NC=CC=C1CNC2=C(C(F)(F)F)C=NC(NC3=CC4=C(C=C3)NC(C4)=O)=N2.O=S(C5=CC=CC=C5)(O)=O
solubility DMSO: 2 mg/mL, clear
storage temp. 2-8°C
Application: PF-562,271 has been used as a focal adhesion kinase (FAK) inhibitor to study its effects on the S100A9-induced tumor cell invasion in prostate cancer cell lines. It has also been used to study its effects on syndecan-1 (SDC-1) knockdown-induced upregulation of early growth regulator 1 (EGR1) in colon cancer cells.
Biochem/physiol Actions: PF-562,271 is a potent, ATP-competitive, reversible and selective inhibitor of FAK and Pyk2. PF-562,271 inhibits FAK phosphorylation in vivo.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 41121800

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