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WYE-125132

SIGMA/PZ0321 - ≥97% (HPLC)

Synonym: N-[4-[1-(1,4-Dioxaspiro[4.5]dec-8-yl)-4-(8-oxa-3-azabicyclo[3.2.1]oct-3-yl)-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-N′-methyl-urea; WYE-132

CAS Number: 1144068-46-1
Empirical Formula (Hill Notation): C27H33N7O4
Molecular Weight: 519.60
Linear Formula: C27H33N7O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0321-5MG 5 mg
 $101.00
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assay ≥97% (HPLC)
color white to beige
form powder
InChI 1S/C27H33N7O4/c1-28-26(35)30-18-4-2-17(3-5-18)23-31-24(33-15-20-6-7-21(16-33)38-20)22-14-29-34(25(22)32-23)19-8-10-27(11-9-19)36-12-13-37-27/h2-5,14,19-21H,6-13,15-16H2,1H3,(H2,28,30,35)
InChI key QLHHRYZMBGPBJG-UHFFFAOYSA-N
Quality Level 100 
SMILES string N6(CC7OC(C6)CC7)c1nc(nc3[n](ncc31)C4CCC5(OCCO5)CC4)c2ccc(cc2)NC(=O)NC
solubility DMSO: 20 mg/mL, clear
storage temp. −20°C
Biochem/physiol Actions: In ovarian cancer cells, WYE-132 might prevent the activity of sphingosine kinase-1 (SphK1), leading to pro-apoptotic ceramide production.
Biochem/physiol Actions: WYE-125132 (WYE-132) is a highly potent, ATP-competitive, and specific inhibitor of mTOR with an IC50 value of 0.19 nM. Unlike rapamycin, which ihibits mTOR through allosteric binding to mTOR complex 1 (mTORC1) only, WYE-132 inhibits both mTORC1 and mTORC2. WYE-125132 is >5000-fold selective for mTOR vs. phosphoinositide 3-kinase (PI3K). WYE-132 induced apoptosis in a variety of cancer lines including LNCap prostate cells and H1975 lung cancer cells. WYE-132 also inhibited ovarian cancer cell growth.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Purity ≥97% (HPLC)
Storage Temp. −20°C
UNSPSC 12352200

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