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PF-05089771

SIGMA/PZ0311 - ≥98% (HPLC)

Synonym: 4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-benzenesulfonamide 4-methylbenzenesulfonate (1:1); 4-[2-(5-Amino-1H-pyrazol-4-yl)-4-chloro-phenoxy]-5-chloro-2-fluoro-N-thiazol-4-yl-benzenesulfonamide p-toluene sulfonate salt; PF-05089771 p-toluene sulfonate salt

CAS Number: 1430806-04-4
Empirical Formula (Hill Notation): C18H12Cl2FN5O3S2 · C7H8O3S
Molecular Weight: 672.56
Linear Formula: C18H12Cl2FN5O3S2 · C7H8O3S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0311-5MG 5 mg
 $119.00
1/EA		 Add To Favorites
45-PZ0311-25MG 25 mg
 $480.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts PZ0311-25MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C18H12Cl2FN5O3S2.C7H8O3S/c19-9-1-2-14(10(3-9)11-6-24-25-18(11)22)29-15-5-13(21)16(4-12(15)20)31(27,28)26-17-7-30-8-23-17;1-6-2-4-7(5-3-6)11(8,9)10/h1-8,26H,(H3,22,24,25);2-5H,1H3,(H,8,9,10)
InChI key NVKBPDYKPNYMDR-UHFFFAOYSA-N
Quality Level 100 
SMILES string ClC1=CC(C2=C(N)NN=C2)=C(OC3=C(Cl)C=C(S(NC4=CSC=N4)(=O)=O)C(F)=C3)C=C1.CC5=CC=C(S(=O)(O)=O)C=C5
solubility DMSO: 30 mg/mL, clear
storage temp. room temp
Biochem/physiol Actions: PF-05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC50 value of 11 nM. PF-05089771 targets the voltage-sensing domain, preferentially interacting with, and stabilizing, inactivated channel conformations by interaction with the voltage-sensor domain (VSD) of Domain 4. Nav1.7 is expressed in sensory neurons and is critical for pain processing. PF-05089771 is being investigated for the treatment of chronic neuropathic pain.
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 12352200

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