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PF-03084014 hydrobromide

SIGMA/PZ0298 - ≥98% (HPLC)

Synonym: (2S)-2-[[(2S)-6,8-Difluoro-1,2,3,4-tetrahydro-2-naphthalenyl]amino]-N-[1-[2-[(2,2-dimethylpropyl)amino]-1,1-dimethylethyl]-1H-imidazol-4-yl]-pentanamide hydrobromide; Nirogacestat; PF 03084014 hydrobromide; PF 3084014 hydrobromide; PF-3084014 hydrobromide

CAS Number: 1290543-63-3 (free base)
Empirical Formula (Hill Notation): C27H41F2N5O · xHBr
Molecular Weight: 489.64 (free base basis)
Linear Formula: C27H41F2N5O · xHBr
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0298-5MG 5 mg
 $129.00
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45-PZ0298-25MG 25 mg
 $535.00
1/EA		 Add To Favorites
This picture is provided solely for illustration purposes, it may have been created or edited with AI. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material.
This image depicts PZ0298-5MG.

 

assay ≥98% (HPLC)
color white to beige
form powder
InChI 1S/C27H41F2N5O.CH4/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4;/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35);1H4/t20-,23-;/m0./s1
InChI key GLEYBLZDOTUZJH-WCRWPNQISA-N
Quality Level 100 
SMILES string FC1=C2C(CC[C@H](N[C@@H](CCC)C(NC3=CN(C(C)(C)CNCC(C)(C)C)C=N3)=O)C2)=CC(F)=C1.C
solubility H2O: 1 mg/mL, clear
storage condition desiccated
storage temp. room temp
Biochem/physiol Actions: PF-03084014 inhibits the Notch signalling pathway. It contributes totumor suppression in breast, pancreatic carcinoma, hepatocellular carcinoma and progressive desmoid tumors. PF-03084014 in combination with dexamethasone elicits antileukemic effects in T-cell acute lymphoblastic leukemias (T-ALL).
Biochem/physiol Actions: PF-03084014 is a highly potent γ-secretase inhibitor that reduces Aβ production in vitro. PF-03084014 does not show a paradoxical increase in plasma Aβ at low concentrations in both preclinical species and humans.
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. room temp
UNSPSC 51111800

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