PF-06658607
SIGMA/PZ0242 - ≥98% (HPLC)
Synonym: (R)
CAS Number: 1621002-24-1
Empirical Formula (Hill Notation): C27H24N6O2
Molecular Weight: 464.52
Linear Formula: C27H24N6O2
Product Type: Chemical
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This image depicts PZ0242-5MG.
This image depicts PZ0242-5MG.
| assay | ≥98% (HPLC) |
| color | white to beige |
| form | powder |
| Quality Level | 100  |
| solubility | DMSO: 20 mg/mL, clear |
| storage temp. | room temp |
| Application: | PF-06658607 has been used to evaluate the proteome-wide selectivity of covalent kinase inhibitors. |
| Biochem/physiol Actions: | PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor that covalently reacts with active-site cysteine residues in the ATP binding pocket. PF-06658607 has been used as a probe for proteomic analysis to identify off-target binding substrates. The alkyne moiety allows for addition of an azide-based detection probe via copper-catalyzed click chemistry methods. |
| Biochem/physiol Actions: | PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor. |
| Packaging: | 5, 25 mg in glass bottle |
| Symbol |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315 - H319 - H335 |
| Precautionary statements | P302 + P352 - P305 + P351 + P338 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥98% (HPLC) |
| Storage Temp. | room temp |
| UNSPSC | 12352200 |