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CP-100356 monohydrochloride

SIGMA/PZ0171 - >98% (HPLC)

Synonym: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine monohydrochloride

CAS Number: 142715-48-8
Empirical Formula (Hill Notation): C31H36N4O6 · HCl
Molecular Weight: 597.10
MDL Number: MFCD00911858
Linear Formula: C31H36N4O6 · HCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-PZ0171-25MG 25 mg
 $603.00
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assay >98% (HPLC)
color white to off-white
form powder
InChI 1S/C31H36N4O6.ClH/c1-36-24-8-7-19(13-25(24)37-2)9-11-32-31-33-23-17-29(41-6)28(40-5)16-22(23)30(34-31)35-12-10-20-14-26(38-3)27(39-4)15-21(20)18-35;/h7-8,13-17H,9-12,18H2,1-6H3,(H,32,33,34);1H
InChI key WWCHXVYTCMPAMV-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.COc1ccc(CCNc2nc(N3CCc4cc(OC)c(OC)cc4C3)c5cc(OC)c(OC)cc5n2)cc1OC
solubility DMSO: >5 mg/mL
storage condition desiccated
storage temp. 2-8°C
Biochem/physiol Actions: CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter.
Biochem/physiol Actions: CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. The compound has low uM to nM potency for inhibiting several MDR-1 substrates (calcein-AM, digoxin) in transfected MDCKII cells. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM).
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Packaging: 5, 25 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity >98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12161501

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