Crisaborole

SIGMA/PZ0037 - ≥98% (HPLC)

Synonym: 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile; 5-(4-Cyanophenoxy)-1,3-dihydro-1-hydroxy-[2,1]-benzoxaborole; 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole; AN2728

CAS Number: 906673-24-3
Empirical Formula (Hill Notation): C₁₄H₁₀BNO₃
Molecular Weight: 251.05
MDL Number: MFCD17169940
Linear Formula: C₁₄H₁₀BNO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-PZ0037-5MG	5 mg	$116.00 1/EA	Add To Favorites
45-PZ0037-25MG	25 mg	$467.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to beige
form	powder
InChI	1S/C14H10BNO3/c16-8-10-1-3-12(4-2-10)19-13-5-6-14-11(7-13)9-18-15(14)17/h1-7,17H,9H2
InChI key	USZAGAREISWJDP-UHFFFAOYSA-N
Quality Level	100
SMILES string	OB1OCC2=C1C=CC(OC3=CC=C(C#N)C=C3)=C2
solubility	DMSO: 10 mg/mL, clear
storage temp.	room temp

Biochem/physiol Actions:	Crisaborole is a non-steroidal anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor.
Biochem/physiol Actions:	Crisaborole is a non-steroidal anti-inflammatory phosphodiesterase 4 (PDE4) inhibitor. Crisaborole has an IC₅₀ value of 490 nM for PDE4 with similar IC₅₀ values for release of cytokines TNF-α, IL-2, and IFN-γ, and shows little inhibition against other PDE isozymes. Crisaborole has been approved as a topical treatment for atopic dermatitis.
Packaging:	5, 25 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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