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Protein Kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt

SIGMA/P9115 - ≥90% (HPLC), lyophilized powder

Empirical Formula (Hill Notation): C53H98N20O12 · C2HF3O2
Molecular Weight: 1321.50
MDL Number: MFCD03788010
Linear Formula: C53H98N20O12 · C2HF3O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P9115-1MG 1 mg
 $366.00
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assay ≥90% (HPLC)
form lyophilized powder
InChI 1S/C53H100N20O12.C2HF3O2/c1-6-8-9-10-11-12-13-14-15-16-17-24-39(76)65-29-40(77)69-35(22-19-26-63-52(58)59)48(83)73-43(33(5)74)50(85)66-30-41(78)68-34(21-18-25-62-51(56)57)46(81)70-36(23-20-27-64-53(60)61)47(82)71-37(28-38(54)75)49(84)67-32(4)45(80)72-42(44(55)79)31(3)7-2;3-2(4,5)1(6)7/h31-37,42-43,74H,6-30H2,1-5H3,(H2,54,75)(H2,55,79)(H,65,76)(H,66,85)(H,67,84)(H,68,78)(H,69,77)(H,70,81)(H,71,82)(H,72,80)(H,73,83)(H4,56,57,62)(H4,58,59,63)(H4,60,61,64);(H,6,7)/t31-,32-,33+,34-,35-,36-,37-,42-,43-;/m0./s1
InChI key DBHNUJXUTKVLID-UXBYPZMDSA-N
Quality Level 100 
SMILES string OC(=O)C(F)(F)F.CCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(N)=O
solubility H2O: soluble
storage temp. −20°C
Amino Acid Sequence: Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2
Application: Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt has been used in cell culture for pharmaceutical inhibition and activation studies.
Biochem/physiol Actions: Cell permeable cAMP-dependent protein kinase (PKA) inhibitor
Biochem/physiol Actions: Mutations in the gene encoding protein kinase cAMP-activated catalytic subunit-α (PRKACA) have been associated with Cushing’s syndrome.
General description: Protein kinase A inhibitor fragment 14-22, myristoylated trifluoroacetate salt inhibits the protein kinase cAMP-activated catalytic subunit-α (PRKACA). The gene encoding it is localized on human chromosome 19p13.1.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥90% (HPLC)
Storage Temp. −20°C
UNSPSC 12352204

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