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5α-Pregnan-3α-ol-20-one

SIGMA/P8887 - solid

Synonym: 3α-Hydroxy-5α-pregnan-20-one; 3α-OH-DHP; Allopregnan-3α-ol-20-one; Allopregnanolone; Brexanolone

CAS Number: 516-54-1
Empirical Formula (Hill Notation): C21H34O2
Molecular Weight: 318.49
MDL Number: MFCD00003677
Linear Formula: C21H34O2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P8887-5MG 5 mg
 $217.00
1/EA		 Add To Favorites
45-P8887-10MG 10 mg
 $261.00
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color white
form solid
InChI 1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3/t14-,15+,16-,17+,18-,19-,20-,21+/m0/s1
InChI key AURFZBICLPNKBZ-SYBPFIFISA-N
Quality Level 200 
SMILES string [H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CC[C@@H](O)C2
solubility DMSO: 5 mg/mL
  methanol: soluble
Application: 5α-Pregnan-3α-ol-20-one has been used:
• as an allosteric modulator of GABAA receptors in mice
• a neuroprotective steroid in transgenic mice
• a neurosteroid
Biochem/physiol Actions: 5α-Pregnan-3α-ol-20-one is a positive allosteric modulator of γ-aminobutyric acid (GABA) A receptor (GABAA). It is also called pregnan and during pregnancy it modulates the atrial volume receptors transducer properties. During estrus cycle, 5α-Pregnan-3α-ol-20-one or allopregnanolone levels changes in hypothalamus. It is present in high levels post adrenalectomy and gonadectomy.
Features and Benefits: This compound is a featured product for Neuroscience research. Click here  to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the GABAA Receptors  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 10 mg in poly bottle
Packaging: 5 mg in glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
UNSPSC 12352200

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