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Ammonium pyrrolidinedithiocarbamate

SIGMA/P8765 - ~99%

Synonym: 1-Pyrrolidinecarbodithioic acid ammonium salt; APDC; Ammonium pyrrolidinecarbodithioate; PDC; PDTC

CAS Number: 5108-96-3
Empirical Formula (Hill Notation): C5H12N2S2
Molecular Weight: 164.29
EC Number: 225-834-4
MDL Number: MFCD00012720
Linear Formula: C5H9NS2 · NH3
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P8765-1G 1 g
 $57.40
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45-P8765-5G 5 g
 $159.00
1/EA		 Add To Favorites
45-P8765-25G 25 g
 $349.00
1/EA		 Add To Favorites
45-P8765-100G 100 g
 $661.00
1/EA		 Add To Favorites

 

assay ~99%
biological source microbial
form (powderor powder with lumps)
InChI 1S/C5H9NS2.H3N/c7-5(8)6-3-1-2-4-6;/h1-4H2,(H,7,8);1H3
InChI key MDDIUTVUBYEEEM-UHFFFAOYSA-N
mp 153-155 °C (lit.)
Quality Level 200 
SMILES string N.SC(=S)N1CCCC1
solubility water: 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow
storage temp. 2-8°C
Application: Ammonium pyrrolidinedithiocarbamate has been used:
• to inhibit nuclear factor κB (NF-κB) mobilization and TNF (tumor necrosis factor) production in human monocytes
• to reduce neutrophil activity in rats
• to prevent Ca2+ influx in adriamycin (ADR)-treated podocytes

to abrogate the microRNA-146a promoter luciferase reporter activity in human brain cells
Biochem/physiol Actions: Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.
General description: Ammonium pyrrolidinedithiocarbamate is a nuclear factor κB (NF-κB) inhibitor. It functions as a chelating agent, which allows the preconcentration of trace metals from solution. Pyrrolidinedithiocarbamate (PDTC) has antioxidant properties. It inhibits apoptosis in lymphocytes, neurons and vascular endothelial cells.
Packaging: 1, 5, 100 g in glass bottle
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ~99%
mp 153-155 °C (lit.)
Storage Temp. 2-8°C
UNSPSC 12352107

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