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Probenecid

SIGMA/P8761

Synonym: p-(Dipropylsulfamoyl)benzoic acid

CAS Number: 57-66-9
Empirical Formula (Hill Notation): C13H19NO4S
Molecular Weight: 285.36
EC Number: 200-344-3
MDL Number: MFCD00038402
Linear Formula: C13H19NO4S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P8761-25G 25 g
 $114.00
1/EA		 Add To Favorites
45-P8761-100G 100 g
 $385.00
1/EA		 Add To Favorites

 

assay ≥98% (NaOH, titration)
InChI 1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
InChI key DBABZHXKTCFAPX-UHFFFAOYSA-N
originator Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level 200 
SMILES string CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
Application: Probenecid has been used:
• as a component of phenol red free Hank′s buffer for Intracellular Ca2+-mobilization assay
• as a component of calcium sensitive dye for calcium mobilization Studies
• as a supplement in Hank′s balanced salt solution (HBSS) assay buffer
Application: Useful as an inhibitor of the organic anion transporter, MRP.
Biochem/physiol Actions: Probenecid is a uricosuric agent, which increases uric acid removal in the urine and reduces urate reuptake. It also reduces the renal tubular excretion of many other drugs and increases their plasma concentration. The inhibitory action of probenecid is mediated by organic anion transporters. It is found useful for the treatment of gout. Probenecid is responsible for the rise in the levels of neurochemicals in the brain by preventing its movement from choroid plexus and parenchyma cells into plasma.
Features and Benefits: This compound is a featured product for ADME Tox research. Click here  to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S. . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Symbol GHS07  GHS07
Signal word Warning
Hazard statements H302
Precautionary statements P301 + P312 + P330
Hazard Codes Xn
Risk Statements 22
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (NaOH, titration)
UNSPSC 12161501

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