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DL-Propargylglycine

SIGMA/P7888 - cystathionine γ-lyase inhibitor

Synonym: 2-Amino-4-pentynoic acid; PAG

CAS Number: 64165-64-6
Empirical Formula (Hill Notation): C5H7NO2
Molecular Weight: 113.11
MDL Number: MFCD00056728
Linear Formula: C5H7NO2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P7888-250MG 250 mg
 $0.00
1/EA
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45-P7888-1G 1 g
 $242.00
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45-P7888-5G 5 g
 $0.00
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application(s) cell analysis
assay ≥98% (TLC)
color white
form powder
InChI 1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8)
InChI key DGYHPLMPMRKMPD-UHFFFAOYSA-N
Quality Level 200 
SMILES string NC(CC#C)C(O)=O
storage temp. −20°C
Application:

  • Metabolic Labeling Strategy Boosted Antibacterial Efficiency for Photothermal and Photodynamic Synergistic Bacteria-Infected Wound Therapy.: This study demonstrates the enhanced antibacterial efficiency of a metabolic labeling strategy using ᴅʟ-Propargylglycine in photothermal and photodynamic therapy for treating bacteria-infected wounds (Li et al., 2022 ).

  • Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables In Vivo Imaging of Gut Microbiota.: This research utilizes ᴅʟ-Propargylglycine for metabolic labeling, allowing near-infrared II imaging of gut microbiota in vivo, providing new insights into microbiome studies (Wang et al., 2020 ).

  • Hydrogen sulfide upregulated mRNA expressions of sodium bicarbonate cotransporter1, trefoil factor1 and trefoil factor2 in gastric mucosa in rats.: Investigates the role of ᴅʟ-Propargylglycine, in upregulating specific mRNA expressions in gastric mucosa, with implications for gastrointestinal research (Cheraghi et al., 2016 ).
Biochem/physiol Actions: DL-Propargylglycine (PAG) is an irreversible inhibitor of the enzyme cystathionine γ-lyase (GCL), a key enzyme involved in glutathione synthesis and the metabolic transsulfuration pathway which regulates homocysteine concentration and mediates cysteine synthesis. Treatment of animal disease models with PAG was shown to alleviate symptoms of diseases that impair the formation or action of hydrogen sulfide (H2S).
Purity ≥98% (TLC)
Storage Temp. −20°C
UNSPSC 12352209

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