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Prazosin hydrochloride

SIGMA/P7791 - ≥99.0% (HPLC)

Synonym: 1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine hydrochloride; Furazosin hydrochloride

CAS Number: 19237-84-4
Empirical Formula (Hill Notation): C19H21N5O4 · HCl
Molecular Weight: 419.86
EC Number: 242-903-4
MDL Number: MFCD00058177
Linear Formula: C19H21N5O4 · HCl
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-P7791-50MG 50 mg
$72.80
1/EA
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45-P7791-250MG 250 mg
$295.00
1/EA
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45-P7791-1G 1 g
$978.00
1/EA
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assay ≥99.0% (HPLC)
form powder
InChI 1S/C19H21N5O4.ClH/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14;/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22);1H
InChI key WFXFYZULCQKPIP-UHFFFAOYSA-N
Quality Level 100 
SMILES string Cl.COc1cc2nc(nc(N)c2cc1OC)N3CCN(CC3)C(=O)c4ccco4
solubility dilute aqueous acid: insoluble
  H2O: 0.5 mg/mL
  methanol: 6 mg/mL
Application: Prazosin hydrochloride has been used:
• to block the α1adrenergic receptors that mediate sympathetic vasoconstriction in mice
• as an α1-adrenoceptor blocker,administered intragastrically in rats
• as a vasodilator,administered together with inuslin into the left ventricle of mice for the assessment of its effects on renal functions

Biochem/physiol Actions: Peripheral α1-adrenoceptor antagonist; vasodilator. Prazosin can be used to treat chronic posttraumatic stress disorder (PTSD). It plays a role in reducing blood pressure by relaxing blood vessels, hence used in the treatment of high blood pressure.
Disclaimer: Hygroscopic; light sensitive.
Features and Benefits: This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox  and Neuroscience  products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits: This compound is featured on the α1-Adrenoceptors , α2-Adrenoceptors  and Melatonin Receptors  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
General description: Prazosin is a member of the class of α-adrenergic blockers. It is considered as a peripheral vasodilator antihypertensive agent. Prazosin is a derivative of quinazoline.
Packaging: Bottomless glass bottle. Contents are inside inserted fused cone.
Purity ≥99.0% (HPLC)
UNSPSC 12352200

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