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1,2-Diacyl-sn-glycero-3-phospho-L-serine

SIGMA/P7769 - ≥97% (TLC), from bovine brain, amorphous powder

Synonym: 3-sn-Phosphatidyl-L-serine; L-α-Phosphatidyl-L-serine; PS; Phosphatidylserine

Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-P7769-5MG 5 mg
$75.20
1/EA
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45-P7769-25MG 25 mg
$258.00
1/EA
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45-P7769-100MG 100 mg
$837.00
1/EA
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Representative of vacuum-sealed clear ampule packaging. Non-uniform tips are an inherent feature in this sealing process.

 

assay ≥97% (TLC)
biological source bovine brain
form amorphous powder
Quality Level 200 
storage temp. −20°C
Application: 1,2-Diacyl-sn-glycero-3-phospho-L-serine has been used:
• as a lipid standard in time-of-flight secondary ion mass spectrometry (ToF-SIMS) spectral fingerprints
• as a reference standard in thin layer chromatography (TLC) for quantifying lipids from astrocyte-conditioned media (ACM) treated fibroblasts
• as a component of large unilamellar vesicles for annexin A2 aggregation studies

Biochem/physiol Actions: 1,2-Diacyl-sn-glycero-3-phospho-L-serine or phosphatidylserine (PS) is a structurally diverse acidic phospholipid having fatty acid ester at the glycerol sn positions. Bovine brain cortex based PS is a potent brain nutrient. It favors neurotransmission and may improve memory in dementia. PS is also the major membrane phospholipid associated with the nuclear membrane, myelin, endoplasmic reticulum, Golgi and mitochondria. The synthesis of PS is catalyzed by phosphatidylserine synthase 1 from L-serine and CDP-diacylglycerol in the mitochondria-associated membrane (MAM) domains of the endoplasmic reticulum. PS is externalized during phagocytosis and is dysregulated in tumors making it a potential marker for therapeutic targeting.
Biochem/physiol Actions: A slowly metabolized structural phospholipid found mainly in gray matter.
Disclaimer: Solutions exposed to room temperature will decompose about 0.5% per day.
Features and Benefits: This compound is featured on the Phospholipase D  and PKC  pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging: 5, 25, 100 mg in ampule
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97% (TLC)
Storage Temp. −20°C
UNSPSC 12352200

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