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Phosphatase Inhibitor Cocktail 2

SIGMA/P5726 - aqueous solution (dark coloration may develop upon storage, which does not affect the activity)

Synonym: Protease inhibitor

Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P5726-1ML 1 mL
 $120.00
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45-P5726-5ML 5 mL
 $416.00
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form aqueous solution (dark coloration may develop upon storage, which does not affect the activity)
Quality Level 200 
  300 
shipped in wet ice
solubility water: soluble
storage temp. 2-8°C
Application: The phosphatase inhibitor cocktail improves the yields of intact proteins by adding inhibitors to enzymes that modify proteins present in cell extracts. This product has been optimized and tested for tyrosine protein phosphatases, acid and alkaline phosphatases. It has been tested on cell extracts from animal tissues including bovine liver and human placenta, and cytosolic extract of rabbit muscle.
Biochem/physiol Actions: This mixture contains individual components with specific inhibitory properties. Sodium orthovanadate inhibits a number of ATPases, protein tyrosine phosphatases, and other phosphate-transferring enzymes. Sodium molybdate inhibits acid and phosphoprotein phosphatases. Sodium tartrate inhibits acid phosphatases. Imidazole inhibits alkaline phosphatases.
Disclaimer: As supplied, this product is stable for two years at the recommended 2-8°C storage temperature.
Features and Benefits: This compound is a featured product for Kinase Phosphatase Biology research. Click here  to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
General description: Phosphatase Inhibitor Cocktail 2 is a mixture of components designed to inhibit enzymes that modify proteins present in cell extracts, leading to improved yields of intact proteins. It has been optimized and tested for use on various animal tissues and cytosolic extracts.
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Preparation Note: This cocktail is supplied as a clear aqueous solution. It has been sterile filtered through a 0.2 μm membrane in bottles that have been aseptically filled. One mL will inhibit phosphatase activities found in the 100,000 x g supernatant from human placenta, bovine liver, rabbit muscle, A431, or Jurkat cell extracts at a protein concentration of approximately 5 mg/mL.
Storage Temp. 2-8°C
UNSPSC 12352200

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