Phenobarbital sodium salt

SIGMA/P5178

Synonym: 5-Ethyl-5-phenyl-2,4,6-trioxohexahydropyrimidine sodium salt; 5-Ethyl-5-phenylbarbituric acid sodium salt; Luminal sodium salt; Sodium 5-ethyl-5-phenylbarbiturate

CAS Number: 57-30-7
Empirical Formula (Hill Notation): C₁₂H₁₁N₂NaO₃
Molecular Weight: 254.22
EC Number: 200-322-3
MDL Number: MFCD00036211
Linear Formula: C₁₂H₁₁N₂NaO₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P5178-25G	25 g	$102.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P5178-25G

Properties
Descriptions
Safety Info.
Basic Data

drug control	kontrollierte Droge in Deutschland
	USDEA Schedule IV; Home Office Schedule 3; psychotrope (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada; psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal); Pszichotróp anyag / Psychotropic Substance (Hungary), 78/2022. (XII. 28.) BM rendelet
form	powder
InChI	1S/C12H12N2O3.Na/c1-2-12(8-6-4-3-5-7-8)9(15)13-11(17)14-10(12)16;/h3-7H,2H2,1H3,(H2,13,14,15,16,17);/q;+1/p-1
InChI key	WRLGYAWRGXKSKG-UHFFFAOYSA-M
originator	Bayer
Quality Level	200
SMILES string	[Na+].CCC1(C(=O)NC([O-])=NC1=O)c2ccccc2
solubility	ethanol: 100 mg/mL
	H₂O: 1 g/mL

Application:	Phenobarbital sodium salt has been used: • to anesthetize mice for inducing ischemia-reperfusion injury • as a positive control for the activation of constitutive androstane receptor (CAR) • in bioluminescent yeast bioreporters (BLYAS) assay
Biochem/physiol Actions:	Phenobarbital, a substituted barbituric acid is an antileptic drug and is not easily eliminated from circulation. It hyperpolarizes the synaptic neuronal membranes by favoring the activation of neuronal postsynaptic GABAA receptors by γ aminobutyric acid (GABA). Phenobarbital is also effective in treating neonatal seizures and status epilepticus.
Biochem/physiol Actions:	Sedative; hypnotic; anticonvulsant; enhances GABAergic activity.
Features and Benefits:	This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm .
Features and Benefits:	This compound is featured on the Dopamine and Norepinephrine Metabolism and GABAA Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Bayer . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Legal Information:	German Dieses Produkt fällt unter das Betäubungsmittelgesetz (BtMG). Für eine Bestellung dieses Produktes ist eine Erlaubnis nach § 3 BtMG zwingend erforderlich, es sei denn, es greift eine Ausnahme von der Erlaubnispflicht nach § 4 oder § 26 BtMG. English This product is subject to the German Narcotics Act. A permit under Section 3 of the German Narcotics Act is mandatory for ordering this product unless an exemption from the permit requirement under Section 4 or Section 26 of the German Narcotics Act applies.

Symbol	GHS06,GHS08
Signal word	Danger
Hazard statements	H301 - H317 - H351
Precautionary statements	P280 - P301 + P310
Hazard Codes	T
Risk Statements	25-40-43
Safety Statements	22-36/37/39-45
RIDADR	UN 2811 6.1 / PGIII
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352202

To Order From a Quote