Pluronic® F-127
SIGMA/P2443 - powder, BioReagent, suitable for cell culture
Synonym: Non-ionic copolymer surfactant
CAS Number: 9003-11-6
MDL Number: MFCD00082049
Linear Formula: (C3H6O·C2H4O)x
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P2443-250G
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P2443-1KG
| CMC | 950-1000 ppm (~25°C) |
| description | contains 100ppm BHT |
| Non-ionic | |
| form | powder |
| HLB | 18 - 23 |
| InChI | 1S/C3H6O.C2H4O/c1-3-2-4-3 |
| InChI key | RVGRUAULSDPKGF-UHFFFAOYSA |
| mol wt | ~12600 g/mol |
| product line | BioReagent |
| Quality Level | 200  |
| SMILES string | O2C(C2)C.O1CC1 |
| technique(s) | cell culture | mammalian: suitable |
| transition temp | cloud point >100 °C |
| Application: | Pluronic® F-127 has been used: • as a delivery system for a peptide to the wound site to study the effect of the peptide on wound healing in mice. • as a surface coating for PDMS (polydimethylsiloxane) stamps to make them hydrogel repellent. • in the preparation of calcium indicator stock solution for measuring neural activities. • as a component of phosphate-buffered saline (PBS), to lower unspecific cell and protein adhesion to a PDMS-based microfluidic device. • This non-ionic copolymer surfactant is suitable for use in insect cell culture applications as an antifoaming agent. |
| Biochem/physiol Actions: | Pluronic® F-127 is a thermo-reversible gel that finds its application in different industries due to its high thermosensitivity, biodegradability, and biocompatibility properties. These properties make this polymer suitable for use as a versatile drug carrier.Pluronic® F-127 improves the therapeutic efficiency of drugs by increasing their bioavailability and thermostability. Additionally, it can promote cellular attachment and collagen formation, which facilitates angiogenesis and tissue regeneration. Due to its efficacy, Pluronic F-127 has been utilized in the encapsulation of mesenchymal stem cells (MSCs) to aid in the regeneration of tissues with low levels of vascularity, such as epithelial tissues, adipose tissues, cartilage, tendons, and bone tissues. |
| General description: | Pluronicpluronic® F-127, also known as poloxamer 407, is a non-toxic and nonionic copolymer. It contains polyethylene oxide-polypropylene oxide arranged in a triblock structure to form PEO-PPO-PEO symmetric. Surfactant properties of this polymer derived from its amphiphilic nature, allow them to interact with hydrophobic surfaces and biological membranes. |
| Legal Information: | Pluronic is a registered trademark of BASF |
| Packaging: | 1 kg in poly bottle |
| Packaging: | 250 g in poly bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 1 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| UNSPSC | 12161902 |