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Picrylsulfonic acid solution

SIGMA/P2297 - 5 % (w/v) in H2O, BioReagent, suitable for determination of primary amines

Synonym: 2,4,6-Trinitrobenzenesulfonic acid solution; TNBS

CAS Number: 2508-19-2
Empirical Formula (Hill Notation): C6H3N3O9S
Molecular Weight: 293.17
MDL Number: MFCD00064382
Linear Formula: C6H3N3O9S
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P2297-10ML 10 mL
 $112.00
1/EA		 Add To Favorites
45-P2297-5X10ML 10 mL
 $448.00
5/EA		 Add To Favorites

 

concentration 5 % (w/v) in H2O
form liquid
InChI 1S/C6H3N3O9S/c10-7(11)3-1-4(8(12)13)6(19(16,17)18)5(2-3)9(14)15/h1-2H,(H,16,17,18)
InChI key NHJVRSWLHSJWIN-UHFFFAOYSA-N
product line BioReagent
Quality Level 200 
SMILES string OS(=O)(=O)c1c(cc(cc1[N+]([O-])=O)[N+]([O-])=O)[N+]([O-])=O
solubility soluble
storage temp. 2-8°C
suitability suitable for determination of primary amines
Application: Hydrophilic modifying reagent. Derivatives with amino compounds can be regenerated with hydrazine.
Application: Picrylsulfonic acid solution has been used:
• to assess the efficiency of carboxymethyl lysine (CML) modifications of exposed primary amines
• to incubate zona intact bovine embryos for the differential staining of blastocysts
• to induce irritable bowel syndrome (IBS) in mice and to study its effects on Clostridium butyricum
General description: Picrylsulfonic acid solution is a hapten, which can bind to tissue proteins and turn into an antigen. This leads to several immunologic responses. Colitis induced by a 2,4,6-trinitrobenzene sulfonic acid (TNBS) is a type of delayed hypersensitivity reaction to haptenized proteins. Leukotriene B4 (LTB4) and the monhydroxyl fatty acids 5-hydroxyeicosatetraenoic acid (5-HETE), 12-HETE, and 15-HETE are the major inflammatory mediators involved in this TNBS-induced colitis. Ethanol when used in high concentration act as a vehicle for the TNBS administration.
Packaging: 10 mL in amber poly bottle
Storage Temp. 2-8°C
UNSPSC 12352005

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