PMA

SIGMA/P1585 - for use in molecular biology applications, ≥99% (HPLC), Molecular Biology

Synonym: Phorbol 12-myristate 13-acetate; NF-κB Activator; PKC Activator; croton oil; phorbol ester; protein kinase C activator; 12-O-Tetradecanoylphorbol 13-acetate; 4β,9α,12β,13α,20-Pentahydroxytiglia-1,6-dien-3-one 12-tetradecanoate 13-acetate; PMA; TPA

CAS Number: 16561-29-8
Empirical Formula (Hill Notation): C₃₆H₅₆O₈
Molecular Weight: 616.83
MDL Number: MFCD00036736
Linear Formula: C₃₆H₅₆O₈
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P1585-1MG	1 mg	$146.00 1/EA	Add To Favorites
45-P1585-5MG	5 mg	$298.00 1/EA	Add To Favorites
45-P1585-10MG	10 mg	$860.00 1/EA	Add To Favorites
45-P1585-25MG	25 mg	$1130.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥99% (HPLC)
form	(Lyophilisate)
grade	Molecular Biology
InChI	1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
InChI key	PHEDXBVPIONUQT-RGYGYFBISA-N
mol wt	616.83 g/mol
Quality Level	200
SMILES string	CCCCCCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(C)=O
solubility	DMSO: soluble (DMSO solutions can be stored dark at −20 °C for at least six months.)
	ethanol: soluble (Dissolve in water-miscible organic solvent prior to preparing aqueous solutions)
storage condition	protect from light
storage temp.	−20°C

Analysis Note:	• Stimulation of interleukin 2 production of Jurkat cells • T-cell stimulation • Protein kinase C (PKC) activator • NF-κB Activator • Promotion of cell growth • Used in analytical studies of tumor promoters • Molecular Biology grade
Application:	PMA has been used: • for the detection of intracellular cytokines • in CellROX oxidative stress assay • for Huh7 cell stimulation to investigate dipeptidyl peptidase 9 (DPP9) re-distribution • as a positive control in B-cell receptor (BCR) stimulation of chronic lymphocytic leukaemia (CLL) cells • in the differentiation of monocytes (THP -1) into macrophages
Application:	Suitable for • molecular biology studies as standard • analytical studies of tumor promoters • promotion of cell growth
Biochem/physiol Actions:	Potent tumor promoter; activates protein kinase C (PKC) in vivo and in vitro.
Disclaimer:	Photosensitive, protect from light.
Features and Benefits:	• Stimulation of interleukin 2 production of Jurkat cells • T-cell stimulation • Protein kinase C (PKC) activator • NF-κB Activator • Promotion of cell growth • Used in analytical studies of tumor promoters • Molecular Biology grade
General description:	Phorbol 12-myristate 13-acetate (PMA) can induce the activity of PLD1 (phospholipase D1) but not PLD2 (phospholipase D2). Through the protein kinase C (PKC) signaling pathway, PMA is a tumor promoter associated with: • gene transcription • cell growth • cell differentiation • programmed cell death • immune pathway • receptor desensitization Phorbol 12-myristate 13-acetate is used to study: • growth factors • hormones • cytokines-mediated regulation of cellular growth and differentiation
General description:	PMA (Phorbol 12-myristate 13-acetate) is an activator of protein kinase C (PKC) and a known tumor promoting agent. PMA also exhibits clastogenic (chromosome-breaking) activity.

Symbol	GHS05,GHS06,GHS08
Signal word	Danger
Hazard statements	H300 + H310 + H330 - H315 - H318 - H351
Precautionary statements	P201 - P202 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	38
Safety Statements	36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥99% (HPLC)
Storage Temp.	−20°C
UNSPSC	12352200

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