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Phaclofen

SIGMA/P118 - solid

Synonym: 3-Amino-2-(4-chlorophenyl)propanephosphonic acid

CAS Number: 114012-12-3
Empirical Formula (Hill Notation): C9H13ClNO3P
Molecular Weight: 249.63
MDL Number: MFCD00069328
Linear Formula: C9H13ClNO3P
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-P118-5MG 5 mg
 $227.00
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45-P118-25MG 25 mg
 $856.00
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45-P118-100MG 100 mg
 $2590.00
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color white
form solid
impurities ≥97% (NMR)
InChI 1S/C9H13ClNO3P/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H2,12,13,14)
InChI key VSGNGLJPOGUDON-UHFFFAOYSA-N
Quality Level 100 
SMILES string NCC(CP(O)(O)=O)c1ccc(Cl)cc1
solubility 0.1 M HCl: 13.3 mg/mL
  DMSO: insoluble
  methanol: 19.3 mg/mL
Application: Phaclofen has been used to block GABAB receptor.
Biochem/physiol Actions: Phaclofen plays a vital role in identifying the physiological importance of central and peripheral bicuculline-insensitive receptors with which GABA and (−) baclofen interact. Phaclofen acts as a GABAB receptor antagonist. Phaclofen has an ability to reversibly block the late, bicuculline resistant, K+ dependent inhibitory postsynaptic potential (IPSP) logged in projection cells of the cat and rat dorsal lateral geniculate nucleus and in rat hippocampal CA1 pyramidal neurons.
General description: Phaclofen is a phosphonic acid derivative of baclofen.
Packaging: 5, 25, 100 mg in glass bottle
UNSPSC 12352200

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