Pyrvinium pamoate salt hydrate

SIGMA/P0027 - ≥98% (HPLC)

Synonym: 6-(Dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-4,4′-methylenebis[3-hydroxy-2-naphthalenecarboxylate] (2:1)-quinolinium; Alnoxin; Altolat; NSC 223622; PP; Pamovin; Vermitibier; Vipyrvinium embonate

CAS Number: 3546-41-6 (anhydrous)
Empirical Formula (Hill Notation): C₂₆H₂₈N₃· 0.5 C₂₃H₁₄O₆ · xH₂O
Molecular Weight: 575.70 (anhydrous basis)
Linear Formula: C₂₆H₂₈N₃· 0.5 C₂₃H₁₄O₆ · xH₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0027-10MG	10 mg	$153.00 1/EA	Add To Favorites
45-P0027-50MG	50 mg	$573.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	red
form	powder
InChI	1S/2C26H28N3.C23H16O6.H2O/c21-19-17-21(20(2)29(19)24-9-7-6-8-10-24)11-13-23-14-12-22-18-25(27(3)4)15-16-26(22)28(23)5;24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;/h26-18H,1-5H3;1-10,24-25H,11H2,(H,26,27)(H,28,29);1H2/q2*+1;;/p-2
InChI key	FGNOZQNUEDSSTR-UHFFFAOYSA-L
Quality Level	100
SMILES string	O.CN(C)c1ccc2[n+](C)c(C=Cc3cc(C)n(c3C)-c4ccccc4)ccc2c1.CN(C)c5ccc6[n+](C)c(C=Cc7cc(C)n(c7C)-c8ccccc8)ccc6c5.Oc9c(cc%10ccccc%10c9Cc%11c(O)c(cc%12ccccc%11%12)C([O-])=O)C([O-])=O
solubility	DMSO: >10 mg/mL
storage temp.	room temp

Application:	Pyrvinium pamoate salt hydrate has been used as an activator of casein kinase 1α (CK1α) in terminal blast phase of chronic myeloid leukemia (BP-CML) and human embryonic kidney (HEK293) cells. It has also been used as an inhibitor of β-catenin in Wilms tumor
Biochem/physiol Actions:	Pyrvinium pamoate is a potent androgen receptor inhibitor.
Biochem/physiol Actions:	Pyrvinium pamoate is a potent androgen receptor inhibitor. Androgen receptors (ARs) are nuclear hormone receptors/transcription factors that reside in the cytoplasm and activated by testosterone and dihydrotestosterone. AR inhibitors have potential therapeutic benefit in prostate cancer; competitive inhibitors and chemical castration methods have been discovered, but both therapies have undesirable side effects and/or resistance potential. A screen for non-competitive inhibitors was performed, resulting in the discovery of pyrvinium as an AR inhibitor. In comparison to competitive inhibitors, this compound does not bind to the ligand-binding domain of AR or block DNA occupancy by AR, but it inhibits AR-dependent gene expression via a distinct signaling mechanism. It is more potent than classical competitive AR antagonists and exhibits synergy with other AR inhibitors.
Features and Benefits:	This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Packaging:	10, 50 mg in glass bottle

Symbol	GHS07,GHS08
Signal word	Warning
Hazard statements	H302 + H312 + H332 - H315 - H319 - H335 - H351
Precautionary statements	P201 - P280 - P301 + P312 + P330 - P302 + P352 + P312 - P304 + P340 + P312 - P308 + P313
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38-40
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	51111800

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