Punicalagin

SIGMA/P0023 - ≥98% (HPLC), from pomegranate

CAS Number: 65995-63-3
Empirical Formula (Hill Notation): C₄₈H₂₈O₃₀
Molecular Weight: 1084.72
MDL Number: MFCD09838017
Linear Formula: C₄₈H₂₈O₃₀
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-P0023-1MG	1 mg	$98.90 1/EA	Add To Favorites
45-P0023-10MG	10 mg	$459.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: P0023-10MG

Properties
Descriptions
Safety Info.
Basic Data

application(s)	metabolomics vitamins, nutraceuticals, and natural products
assay	≥98% (HPLC)
biological source	pomegranate
color	faintly yellow to dark yellow
form	powder
InChI	1S/C48H28O30/c49-10-1-6-17(31(59)27(10)55)19-23-21-22-24(47(70)76-38(21)35(63)33(19)61)20(34(62)36(64)39(22)75-46(23)69)18-9(4-13(52)28(56)32(18)60)43(66)74-37-14(5-72-42(6)65)73-48(71)41-40(37)77-44(67)7-2-11(50)25(53)29(57)15(7)16-8(45(68)78-41)3-12(51)26(54)30(16)58/h1-4,14,37,40-41,48-64,71H,5H2/t14-,37-,40+,41-,48?/m1/s1
InChI key	ZJVUMAFASBFUBG-UYMKNUMKSA-N
Quality Level	100
SMILES string	OC1O[C@@H]2COC(=O)c3cc(O)c(O)c(O)c3-c4c(O)c(O)c5OC(=O)c6c(c(O)c(O)c7OC(=O)c4c5-c67)-c8c(O)c(O)c(O)cc8C(=O)O[C@H]2[C@@H]9OC(=O)c%10cc(O)c(O)c(O)c%10-c%11c(O)c(O)c(O)cc%11C(=O)O[C@@H]19
solubility	methanol: 5 mg/mL, clear
storage temp.	2-8°C

Application:	Punicalagin has been used in the inhibition assay to check its anti-fungal effects on two C. albicans strains. It has also been used as a polyphenolic compound to probe pyroptosis in macrophages and monocytes.
Biochem/physiol Actions:	Potent immune suppressant isolated from pomegranate.
Biochem/physiol Actions:	Punicalagin exhibits an antioxidant effect. Ellagitannins like punicalagin cannot be absorbed directly in humans. First, it converts to ellagic acid, which is further converted to bioavailable urolithin A derivative by human colonic microflora. It elicits an inhibitory effect on nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathway which in turn protects against cancer, neuroinflammation, oxidative stress and memory impairment. It has antimicrobial and antibiofilm activities against S. aureus.
General description:	Punicalagin is one of the main ellagitannins (ETs) or hydrolyzable tannins present in pomegranate. The chemical structure of punicalagin consists of gallagic acid and ellagic acid connected through a glucose molecule. It has two (α and β) isomeric forms that can be found in the pomegranate.
Packaging:	1, 10 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥98% (HPLC)
Storage Temp.	2-8°C
UNSPSC	12352205

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