Oxytocin acetate salt hydrate

SIGMA/O6379 - ≥97% (HPLC)

Synonym: α-Hypophamine

CAS Number: 50-56-6 (free base)
Empirical Formula (Hill Notation): C₄₃H₆₆N₁₂O₁₂S₂
Molecular Weight: 1007.19
EC Number: 200-048-4
MDL Number: MFCD00133730
Linear Formula: C₄₃H₆₆N₁₂O₁₂S₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-O6379-1MG	1 mg	$79.30 1/EA		Add To Favorites
45-O6379-5MG	5 mg	$259.00 1/EA		Add To Favorites
45-O6379-25MG	25 mg	$884.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (HPLC)
biological source	synthetic (organic)
form	powder
InChI	1S/C43H66N12O12S2/c1-5-22(4)35-42(66)49-26(12-13-32(45)57)38(62)51-29(17-33(46)58)39(63)53-30(20-69-68-19-25(44)36(60)50-28(40(64)54-35)16-23-8-10-24(56)11-9-23)43(67)55-14-6-7-31(55)41(65)52-27(15-21(2)3)37(61)48-18-34(47)59/h8-11,21-22,25-31,35,56H,5-7,12-20,44H2,1-4H3,(H2,45,57)(H2,46,58)(H2,47,59)(H,48,61)(H,49,66)(H,50,60)(H,51,62)(H,52,65)(H,53,63)(H,54,64)
InChI key	XNOPRXBHLZRZKH-UHFFFAOYSA-N
Quality Level	200
shipped in	ambient
SMILES string	CCC(C)C1NC(=O)C(Cc2ccc(O)cc2)NC(=O)C(N)CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC1=O)C(=O)N3CCCC3C(=O)NC(CC(C)C)C(=O)NCC(N)=O
solubility	water: 10 mg/mL, clear, colorless
sterility	non-sterile
storage temp.	−20°C

Amino Acid Sequence:	Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2 [Disulfide Bridge: 1-6]
Application:	Oxytocin acetate salt hydrate has been used in cell proliferation assay and is used in experiments to study the effect of oxytocin in the prelimbic (PL) region of the medial prefrontal cortex (mPFC) on anxiety. It is used as a marker in receptor autoradiography to assess nonspecific tissue binding in the periphery of the neonatal mouse.
Biochem/physiol Actions:	Oxytocin (OXT) and arginine vasopressin hormone plays a vital role in regulation of water excretion, parturition and lactation. OXT has been implicated in hydromineral homeostasis and vascular and cardiac relaxation. Oxytocin might function as an effective therapeutic for psychiatric diseases, including depression, schizophrenia, anxiety disorders, and autism. OXT has a potential as a marker of autism severity. OXT is an anorexigenic neuropeptide, which is implicated in social cognition and obsessive-compulsive behavior. Plasma oxytocin levels are high in children with Prader-willi syndrome (PWS) compared with unrelated and unaffected siblings. Deficiency of OXT hormone might contribute to pathogenesis of attention deficit/hyperactivity disorder (ADHD).
Biochem/physiol Actions:	Stimulates uterine contraction and lactation; increases Na⁺ excretion; stimulates myometrial GTPase and phospholipase C.
General description:	Oxytocin (OXT) is a potent natriuretic hormone encoded by the gene mapped to human chromosome 20p13. It is synthesized along with its carrier protein neurophysin I from its inactive precursor prepro-OXT. OXT gene consists of three exons and two introns, where first exon codes for hormone OXT while other exon codes for neurophysin I.

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (HPLC)
Storage Temp.	−20°C
UNSPSC	51111800

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