N_ω-Nitro-L-arginine methyl ester hydrochloride

SIGMA/N5751 - ≥97% (TLC), powder

Synonym: L-NAME HCl; L-NAME hydrochloride

CAS Number: 51298-62-5
Empirical Formula (Hill Notation): C₇H₁₅N₅O₄ · HCl
Molecular Weight: 269.69
EC Number: 257-116-1
MDL Number: MFCD00039052
Linear Formula: C₇H₁₅N₅O₄ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N5751-250MG	250 mg	$26.50 1/EA	Add To Favorites
45-N5751-1G	1 g	$55.10 1/EA	Add To Favorites
45-N5751-5G	5 g	$147.00 1/EA	Add To Favorites
45-N5751-10G	10 g	$214.00 1/EA	Add To Favorites
45-N5751-25G	25 g	$503.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: N5751-25G

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97% (TLC)
biological source	synthetic
color	white to off-white
form	powder
InChI	1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChI key	QBNXAGZYLSRPJK-JEDNCBNOSA-N
mp	132 °C
Quality Level	200
SMILES string	Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
solubility	H₂O: 50 mg/mL
storage temp.	−20°C

Application:	Nω-Nitro-L-arginine methyl ester hydrochloride has been used: • to study the effects of brain-derived neurotrophic factor against neurotoxicity in rat cortical neurons • to study its effect on far-infrared (FIR) enhanced microcirculation of rat skin • to study its effect on leptin-induced regulation of myokine fibronectin type III domain containing five/irisin in murine myocytes and fat cells • to study its effect on the levels of arginine vasopressin and neuronal nitric oxide synthase mRNA levels in hypothalamic paraventricular nucleus and supraoptic nucleus of rat
Biochem/physiol Actions:	Arginine analog that inhibits NO production.
General description:	Nω-Nitro-L-argininemethyl ester hydrochloride or L -NAME HCl, ananalog of arginine, inhibits NO production. It has multiple effects on thevascular system. Inhibits relaxation induced by acetylcholine and induces anincrease in arterial blood pressure. Abolishes lecithinized superoxidedismutase induced vasodilation when used to pretreat aortic ring preparationsof mice. Induces leukocyte adhesion and increases microvascular fluid andprotein fluxes and permeability. It has also been used in many studies oflearning and memory.
Packaging:	1, 5, 10, 25 g in poly bottle
Packaging:	250 mg in poly bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97% (TLC)
mp	132 °C
Storage Temp.	−20°C
UNSPSC	12352209

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