Nebivolol hydrochloride

SIGMA/N1915 - ≥98% (HPLC)

Synonym: Narbivolol; Nebilet; R-65824; rel-(aR,a′R,2R,2′S)-a,a′-[iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] hydrochloride

CAS Number: 152520-56-4
Empirical Formula (Hill Notation): C₂₂H₂₅F₂NO₄ · HCl
Molecular Weight: 441.90
Linear Formula: C₂₂H₂₅F₂NO₄ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-N1915-10MG	10 mg	$90.50 1/EA	Add To Favorites
45-N1915-50MG	50 mg	$403.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥98% (HPLC)
color	white to off-white
form	powder
InChI	1S/C22H25F2NO4.ClH/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22;/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2;1H/t17-,18-,21-,22+;/m0./s1
InChI key	JWEXHQAEWHKGCW-BIISKSHESA-N
originator	Forest Labs
Quality Level	100
SMILES string	Cl.O[C@@H](CNC[C@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@H]3CCc4cc(F)ccc4O3
solubility	DMSO: ≥20 mg/mL
storage condition	desiccated
storage temp.	room temp

Application:	Nebivolol hydrochloride has been used as a standard in the validation of high-performance thin-layer chromatography (HPTLC)-densitometry method. It may be used in calibration curve preparation and absorption spectrum studies using spectrophotometry.
Biochem/physiol Actions:	Nebivolol hydrochloride (NEB) is used as a racemic mixture for clinical studies. It stabilizes membrane and possesses intrinsic sympathomimetic functionality. Nebivolol interaction with π-acceptors (2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), 2,4-dinitrophenol (DNP) and 2,4,6-trinitrophenol (picric acid; PA)) is useful in the spectrophotometric detection methods.
Biochem/physiol Actions:	Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension.
Biochem/physiol Actions:	Nebivolol is a competitive, highly selective b1-receptor antagonist with mild vasodialating properties, possibly due to an interaction with the L-arginine/ NO pathway, and is used for treatment of essential hypertension. It is 40-fold selective for β1 vs. β2, and lacks ISA (intrinsic sympathomimetic activity).
Features and Benefits:	This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits:	This compound was developed by Forest Labs . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging:	10, 50 mg in glass bottle

Hazard Codes	Xn,N
Risk Statements	22-50/53
Safety Statements	60-61
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥98% (HPLC)
Storage Temp.	room temp
UNSPSC	12352200

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