Neomycin solution

SIGMA/N1142 - with 10 mg/mL neomycin in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

Synonym: Antibiotic 10676; Neomycin B

Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-N1142-20ML	20 mL	$18.60 1/EA		Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	Gram-negative bacteria
	Gram-positive bacteria
biological source	Streptomyces fradiae
color	clear
concentration	10 mg/mL in 0.9% NaCl (neomycin)
form	liquid
impurities	endotoxin, tested
InChI	1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChI key	PGBHMTALBVVCIT-VCIWKGPPSA-N
mode of action	protein synthesis \| interferes
packaging	pkg of 20ML
potency	8-12 mg per mL
product line	BioReagent
Quality Level	200
SMILES string	NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)[C@H](N)[C@@H](O)[C@@H]1O
sterility	0.1 μm filtered
storage temp.	2-8°C
technique(s)	cell culture \| mammalian: suitable
UniProt accession no.	O14746

Application:	Neomycin solution has been used: • as a supplement of autoclaved acidified water for bone marrow transplantation • for the selection of stable clones • as a component of artificial sea water (ASWO) medium to remove bacteria from O. tauri cultures
Biochem/physiol Actions:	Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L. Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca²⁺ channels without affecting the Na⁺/Ca²⁺ antiporter in neurons. Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria
Disclaimer:	This solution is formulated to contain 10 mg/mL neomycin in 0.9% sodium chloride. It is stable at 37 °C for 5 days and should be otherwise stored at 2-8°C.
General description:	Chemical structure: aminoglycoside

Symbol	GHS08
Signal word	Danger
Hazard statements	H317 - H334
Precautionary statements	P261 - P280 - P284 - P304 + P340 - P333 + P313 - P342 + P311
Hazard Codes	Xn
Risk Statements	42/43
Safety Statements	23-36/37-45
RIDADR	NONH for all modes of transport
WGK Germany	WGK 2
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352207

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