Minocycline hydrochloride

SIGMA/M9511 - powder

Synonym: Minomycin

CAS Number: 13614-98-7
Empirical Formula (Hill Notation): C₂₃H₂₇N₃O₇ · HCl
Molecular Weight: 493.94
EC Number: 237-099-7
MDL Number: MFCD00083669
Linear Formula: C₂₃H₂₇N₃O₇ · HCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-M9511-25MG	25 mg	$41.40 1/EA	Add To Favorites
45-M9511-100MG	100 mg	$111.00 1/EA	Add To Favorites
45-M9511-250MG	250 mg	$184.00 1/EA	Add To Favorites
45-M9511-1G	1 g	$557.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M9511-100MG

Properties
Descriptions
Safety Info.
Basic Data

antibiotic activity spectrum	mycobacteria
form	powder
InChI	1S/C23H27N3O7.ClH/c1-25(2)12-5-6-13(27)15-10(12)7-9-8-11-17(26(3)4)19(29)16(22(24)32)21(31)23(11,33)20(30)14(9)18(15)28;/h5-6,9,11,17,27,29-30,33H,7-8H2,1-4H3,(H2,24,32);1H/t9-,11-,17-,23-;/m0./s1
InChI key	GLMUAFMGXXHGLU-VQAITOIOSA-N
mode of action	protein synthesis \| interferes
originator	Teva
Quality Level	200
SMILES string	Cl.CN(C)[C@H]1[C@@H]2C[C@@H]3Cc4c(ccc(O)c4C(=O)C3=C(O)[C@]2(O)C(=O)C(C(N)=O)=C1O)N(C)C
storage temp.	2-8°C

Application:	Minocycline hydrochloride has been used: • to prepare nanoliposomes to check its effect on macrophages • for the inhibition of neuroinflammation and neuropathic pain • to treat glioma in murine GL261 glioma cells
Biochem/physiol Actions:	Minocycline is a broad spectrum antibiotic with bacteriostatic function. Minocycline has anti-inflammatory properties. Minocycline inhibits lipopolysaccharide mediated inflammatory cytokine tumour necrosis factor (TNF-α) secretion by macrophages. Minocycline inhibits macrophage proliferation in a dose dependent manner. Minocycline inhibits neuroinflammation in pre-plaque of Alzheimer′s disease-like amyloid pathology through inhibition of key inflammatory enzymes like inducible nitric oxide synthase (iNOS), matrix metalloproteinase 9 (MMP-9) and 5-lipoxygenase. Minocycline inhibits endothelial cell proliferation and angiogenesis. Minocycline exhibits anti-tumor activity in glioma by inhibiting membrane type 1 matrix metalloproteinase (MT1-MMP). Minocycline increases cognition and neuronal differentiation. zMinocycline effectively reduces neuropathic pain by increasing the functions of nociceptin/orphanin FQ.
Features and Benefits:	This compound was developed by Teva . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
General description:	Chemical structure: tetracycline
General description:	Minocycline, a semi-synthetic second-generation tetracycline, is classified within the tetracycline class of antibiotics and is utilized for the management and treatment of both infectious and non-infectious conditions. Apart from its efficacy against gram-positive and gram-negative bacteria, minocycline also exhibits antioxidant, anti-apoptotic, immunomodulatory, and neuroprotective properties. Tetracyclines, including minocycline, function by binding to the 30S ribosomal subunit, thereby preventing charged tRNA from delivering amino acids to elongate the protein chain and form cellular protein. This disruption results in a bacteriostatic effect on the prokaryotic cell, leading to the loss of its ability to grow or replicate. Being lipid-soluble compounds, tetracyclines can traverse hydrophobic barriers such as biological membranes. Among tetracyclines, minocycline demonstrates higher lipophilicity than doxycycline, leading to increased concentrations in the central nervous system (CNS) and the skin.
Packaging:	1 g in poly bottle
Packaging:	100, 250 mg in poly bottle
Packaging:	25 mg in glass bottle
Packaging:	Bottomless glass bottle. Contents are inside inserted fused cone.

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352200

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