Microsomes from Liver, Pooled
SIGMA/M9066 - from rat(Sprague-Dawley), male
Synonym: Liver microsome preparation
Product Type: Chemical
| biological source | rat (Sprague-Dawley) |
| form | liquid |
| packaging | vial of ~10 mg |
| Quality Level | 200  |
| shipped in | dry ice |
| storage temp. | −70°C |
| Application: | Microsomes from Liver, Pooled has been used in following studies: • inhibition of microsomal lipid peroxidation. • hydroxylation of isorhynchophylline (ISOR) in rats. |
| Biochem/physiol Actions: | Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions. |
| Biochem/physiol Actions: | Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β2,2-amino acid derivatives. |
| Biochem/physiol Actions: | Source of drug metabolizing enzymes, including cytochrome P-450. |
| General description: | Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA). |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −70°C |
| UNSPSC | 12161501 |