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(R)-MG132

SIGMA/M8699

Synonym: Z-L-Leu-D-Leu-L-Leu-al

CAS Number: 1211877-36-9
Empirical Formula (Hill Notation): C26H41N3O5
Molecular Weight: 475.62
Linear Formula: C26H41N3O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M8699-1MG 1 mg
 $197.00
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assay ≥98%
InChI 1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1
InChI key TZYWCYJVHRLUCT-VABKMULXSA-N
Quality Level 200 
SMILES string CC(C)C[C@@H](C(N[C@H](C(N[C@H](C=O)CC(C)C)=O)CC(C)C)=O)NC(OCC1=CC=CC=C1)=O
solubility DMSO or DMF: 25 mg/mL
storage temp. −20°C
Application: (R)-MG132 has been used in ubiquitination assay and is used as a proteasome inhibitor.
Biochem/physiol Actions: MG132 (carbobenzoxy-Leu-Leu-leucinal) is a tri-peptide aldehyde. It possesses antitumor activity and boosts cytostatic/cytotoxic effects of chemo- and radiotherapy. (R)-MG132 is a potent, membrane-permeable proteasome inhibitor. It can inhibit proteasome activity in lysates of J558L multiple myeloma cells and EMT6 breast cancer cells. The (R)-MG132 stereoisomer is a more effective inhibitor of chymotrypsin-like (ChTL), trypsin-like (TL), and peptidylglutamyl peptide hydrolyzing proteasome (PGPH) activities than the (S)-MG132.
Other Notes: 2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research 
Physical form: crystalline solid or supercooled liquid
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98%
Storage Temp. −20°C
UNSPSC 12352200

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