Synonym: (1S,2S)-2-[2[[3-(2-Benzimidazolyl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride hydrate; Ro 40-5967 hydrate
CAS Number: 116666-63-8 (anhydrous)
Empirical Formula (Hill Notation): C29H38FN3O3 · 2HCl · xH2O
Molecular Weight: 568.55 (anhydrous basis)
MDL Number: MFCD11044451
Linear Formula: C29H38FN3O3 · 2HCl · xH2O
Product Type: Chemical
| assay |
≥98% (HPLC) |
| color |
white |
| form |
powder |
| InChI |
1S/C29H38FN3O3.2ClH.H2O/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H;1H2/t28-,29-;;;/m0.../s1 |
| InChI key |
IZSWBBGKLWFDOC-YKXHUFBBSA-N |
| originator |
Roche |
| Quality Level |
100  |
| SMILES string |
O.Cl.Cl.COCC(=O)O[C@]3(CCN(C)CCCc1nc2ccccc2[nH]1)CCc4cc(F)ccc4[C@@H]3C(C)C |
| solubility |
absolute ethanol: insoluble |
| |
H2O: soluble >20 mg/mL |
| storage condition |
desiccated |
| Application: |
Mibefradil has been used as a T-type calcium channel blocker in various cells. It has also been used to reduce apoptosis of retinal ganglion cells (RGC) in EphB2-Fc. |
| Biochem/physiol Actions: |
Mibefradil is a tetralol derivative and nondihydropyridine calcium channel blocker. It blocks long-type (L-type) calcium channels. It blocks mildly the Purkinje-type (P-type) calcium channels in Purkinje neurons. |
| Biochem/physiol Actions: |
Ro 40-5967 is a T-type Ca2+ channel blocker; antihypertensive. |
| Features and Benefits: |
This compound was developed by Roche . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here . |
| Packaging: |
5, 25 mg in glass bottle |
| Symbol |
 GHS07 |
| Signal word |
Warning |
| Hazard statements |
H302 |
| RIDADR |
NONH for all modes of transport |
| WGK Germany |
WGK 3 |
| Flash Point(F) |
Not applicable |
| Flash Point(C) |
Not applicable |
| Purity |
≥98% (HPLC) |
| UNSPSC |
12352200 |
