Advanced Search



PX 12

SIGMA/M5324 - ≥98% (HPLC), powder

Synonym: 2-[(1-methylpropyl)dithio]-1H-imidazole

CAS Number: 141400-58-0
Empirical Formula (Hill Notation): C7H12N2S2
Molecular Weight: 188.31
MDL Number: MFCD18086851
Linear Formula: C7H12N2S2
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M5324-5MG 5 mg
 $154.00
1/EA		 Add To Favorites
45-M5324-25MG 25 mg
 $618.00
1/EA		 Add To Favorites

 

assay ≥98% (HPLC)
color off-white to tan
form powder
InChI 1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
InChI key BPBPYQWMFCTCNG-UHFFFAOYSA-N
Quality Level 100 
SMILES string CCC(C)SSc1ncc[nH]1
solubility DMSO: >25 mg/mL
storage temp. 2-8°C
Application: PX 12 has been used as a thioredoxin 1 inhibitor prostate cancer cell lines to analyse its effect on cell viability. It has also been used as a hypoxia-inducible factor (HIF)-1α inhibitor to treat H2228 cells.
Biochem/physiol Actions: PX 12 is a thioredoxin inhibitor.
Biochem/physiol Actions: PX-12 inhibits the thioredoxin redox system and HIF-1a activity. PX 12 inhibits hypoxia-induced HIF-1a transcriptional activity (IC50 11 nM) and proliferation of HT29 and MCF-7 tumor cells (IC50 1.9 and 0.9 uM, respectively).
Packaging: 5, 25 mg in glass bottle
Purity ≥98% (HPLC)
Storage Temp. 2-8°C
UNSPSC 12352200

The following items have been added to your cart:

Choose a favorite list for this item:
Catalog Number Description Price
$

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.


Quick Order

* Required


New Tariffs & Effects on Pricing

Tariff note: As we navigate the current environment of tariff surcharges and mid-year manufacturer price increases, we want to keep you informed. While we have avoided making specific decisions thus far, we anticipate that we will be forced to implement a cost adjustment policy to offset the fees we have already been absorbing. We are committed to transparency and moderation in this process.

800-334-7725
office@krackeler.com


Play Video

To Request a Quote

  1. Search or Browse for items and add to them to your Shopping Cart.
  2. Click the "Request Quote" button at the bottom of the Shopping Cart page.
  3. Fill out required fields.
  4. Optionally you can convert to standard checkout mode by choosing a payment type.
  5. Click "Request Quote" at the bottom of the page.

You will be contacted with a quote.

To Order From a Quote

  1. Register and login to the website.
  2. Receive a quote from your sales representative or customer service.
  3. Have your copy of the quote in hand.
  4. Visit our quote module to search for your quote.
Back to Top