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Mycophenolic acid

SIGMA/M5255 - ≥98%

Synonym: 6-(1,3-Dihydro-7-hydroxy-5-methoxy-4-methyl-1-oxoisobenzofuran-6-yl)-4-methyl-4-hexanoic acid; 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic acid; NSC 129185

CAS Number: 24280-93-1
Empirical Formula (Hill Notation): C17H20O6
Molecular Weight: 320.34
EC Number: 246-119-3
MDL Number: MFCD00036814
Linear Formula: C17H20O6
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M5255-50MG 50 mg
 $103.00
1/EA		 Add To Favorites
45-M5255-250MG 250 mg
 $354.00
1/EA		 Add To Favorites

 

assay ≥98%
biological source Penicillium brevicompactum
color white to yellow-white
InChI 1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+
InChI key HPNSFSBZBAHARI-RUDMXATFSA-N
mode of action enzyme | inhibits
mp <143.0 °C
originator Novartis
Quality Level 300 
SMILES string COc1c(C)c2COC(=O)c2c(O)c1CC=C(/C)CCC(O)=O
solubility methanol: 49.00-51.00 mg/mL, clear, colorless to faintly yellow
storage temp. 2-8°C
Application: Mycophenolic acid (MPA), produced by Penicillum brevi-compactum, is a selective inhibitor of inosine monphosphate dehydrogenase, thus inhibiting DNA synthesis in T and B lymphocytes. It has also been shown to act as an immunosuppressive agent, and as an inducer of monocyte differentiation and apoptosis in human lymphoid and monocytic cell lines. As a selection agent, MPA is used for transfected animal cells expressing the E. Coli gene for xanthine-guanine phosphoribosyl transferase, and is recommended for use at 25μg/mL.
Biochem/physiol Actions: Mode of Action: This product acts by suppressing the cytokine-induced nitric oxide production, inhibiting early stage biosynthesis of purine nucleotides and as a specific inhibitor of IMP dehydrogenase.
Disclaimer: As supplied, this product should be stored desiccated at 2-8°C, and is stable for 5 years when stored properly.
Features and Benefits: This compound was developed by Novartis . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Packaging: 50, 250 mg in serum bottle
Preparation Note: Mycophenolic acid is soluble in methanol at 50 mg/mL, yielding a colorless to faint yellow solution, as well as chloroform, dichloromethane, ethanol and .1 N NaOH. After reconstitution, the recommendation is to sterilize via filtration thorugh a 0.22 μm pore-size filter, aliquot, and freeze at -20°C.
Purity ≥98%
mp <143.0 °C
Storage Temp. 2-8°C
UNSPSC 12352106

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