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Minoxidil

SIGMA/M4145 - ≥99% (TLC)

Synonym: 6-(1-Piperidinyl)-2,4-pyrimidinediamine 3-oxide; 6-(1-Piperidinyl)pyrimidine-2,4-diamine 3-oxide

CAS Number: 38304-91-5
Empirical Formula (Hill Notation): C9H15N5O
Molecular Weight: 209.25
EC Number: 253-874-2
MDL Number: MFCD00063409
Linear Formula: C9H15N5O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M4145-25MG 25 mg
 $91.30
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45-M4145-100MG 100 mg
 $203.00
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45-M4145-250MG 250 mg
 $547.00
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45-M4145-500MG 500 mg
 $967.00
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assay ≥99% (TLC)
InChI 1S/C9H15N5O/c10-7-6-8(12-9(11)14(7)15)13-4-2-1-3-5-13/h6,11,15H,1-5,10H2
InChI key ZIMGGGWCDYVHOY-UHFFFAOYSA-N
mp 272-274 °C (dec.) (lit.)
originator Johnson & Johnson
Quality Level 100 
SMILES string NC1=CC(=NC(=N)N1O)N2CCCCC2
Application: Minoxidil has been used as test drug:
• in dermal papilla spheroid model, to study the effect of hair regeneration
• administered orally to experimental rats, in the approach to identify biomarkers of drug induced vascular injury
• administered via oral gavage to nonhuman primate model in order to study its effect on tilt responses
Biochem/physiol Actions: Activates ATP-activated K+ channels; vasodilator; slow or stop hair loss and promote hair regrowth.
Biochem/physiol Actions: Minoxidil is originally used to treat hypertension, which also induces hypertrichosis. It is considered as a potent drug for treating androgenetic alopecia.
Features and Benefits: This compound is featured on the Potassium Channels  page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here .
Features and Benefits: This compound was developed by Johnson & Johnson . To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here .
Purity ≥99% (TLC)
mp 272-274 °C (dec.) (lit.)
UNSPSC 12352200

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