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β,γ-Methyleneguanosine 5′-triphosphate sodium salt

SIGMA/M3509 - ≥98% (HPLC)

Synonym: GMPPCP; GppCp; Guanosine-5′-[(β,γ)-methyleno]triphosphate sodium salt

CAS Number: 10470-57-2
Empirical Formula (Hill Notation): C11H18N5O13P3 · xNa+
Molecular Weight: 521.21 (free acid basis)
MDL Number: MFCD00070117
Linear Formula: C11H18N5O13P3 · xNa+
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-M3509-25MG 25 mg
 $302.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: M3509-25MG

 

assay ≥98% (HPLC)
biological source synthetic (organic)
form powder
InChI 1S/C11H18N5O13P3.Na.H/c12-11-14-8-5(9(19)15-11)13-2-16(8)10-7(18)6(17)4(28-10)1-27-32(25,26)29-31(23,24)3-30(20,21)22;;/h2,4,6-7,10,17-18H,1,3H2,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,14,15,19);;
InChI key LJQPGKRRFLMZPX-UHFFFAOYSA-N
Quality Level 200 
SMILES string [Na].NC1=NC(=O)c2ncn(C3OC(COP(O)(=O)OP(O)(=O)CP(O)(O)=O)C(O)C3O)c2N1
solubility water: 50 mg/mL, clear, colorless
storage temp. −20°C
Application: βγ-Methyleneguanosine 5′-triphosphate (GMPPCP, GppCp) is a non-hydrolyzable analog of GTP used in a variety of applications that involve GTP binding including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis and GTP structure stabilization. GMPPCP (GuoPP[CH2MP) is used to modulate and study G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Application: β,γ-Methyleneguanosine 5′-triphosphate sodium salt has been used as a GTP analog to complex with dynamin for cryo-electron microscopy studies. It has also been used to complex with Di-Ras1/Di-Ras2 and nucleotide exchange delivery studies.
Biochem/physiol Actions: βγ-Methyleneguanosine 5′-triphosphate (GMPPCP) is used in a variety of applications that involve GTP binding including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis and GTP structure stabilization. GMPPCP is used to modulate and study G proteins involved in cell signaling, protein synthesis and other metabolic processes.
General description: βγ-Methyleneguanosine 5′-triphosphate (GMPPCP, GppCp) is a non-hydrolyzable analog of GTP.
Packaging: 25 mg in poly bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥98% (HPLC)
Storage Temp. −20°C
UNSPSC 41106305

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